JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-N08

SIGNALMENT (JPC #2019038):  Female B6C3F1 mouse

HISTORY:  This mouse had a large cystic abdominal mass.

HISTOPATHOLOGIC DESCRIPTION:  Ovary: Effacing 90% of normal ovarian architecture and compressing remaining ovarian follicles and stroma is an unencapsulated, poorly demarcated, densely cellular, multiloculated neoplasm composed of tissue differentiated toward all three primordial germ cell lines. Ectodermal elements consist of neural tissue and cysts lined by frequently keratinizing squamous epithelium.  Neural tissue consists of neurons, glial cells, and clusters of small, hyperchromatic primitive neuroblastic cells embedded in neuropil.  Cysts are lined by stratified squamous epithelium that multifocally exhibits gradual keratinization through a granular cell layer and are filled by variable amounts of lamellated keratin and keratin debris with few neutrophils or eosinophilic to amphophilic, homogeneous to fibrillar material.  Endodermal elements include numerous variably sized cysts up to 3 mm in diameter which are either lined by a single layer of cuboidal epithelium with multifocal subjacent tubules or pseudostratified columnar epithelium with multifocal cilia and goblet cells (respiratory epithelium) admixed with several small foci of gastric mucosa with mucous neck cells and fewer parietal cells.  Mesodermal elements consist of dermal collagen with melanomacrophages and bundles of smooth muscle.  Mitoses in all cell populations average less than 1 per 10 HPF.

MORPHOLOGIC DIAGNOSIS:  Ovary: Teratoma, B6C3F1 mouse, rodent.

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS:

TYPICAL MICROSCOPIC FINDINGS:

Ectoderm

Mesoderm

Endoderm

Epidermis of skin and its derivatives (sweat glands, hair follicles)

Notochord

Epithelial lining of digestive tract, salivary gland

Epithelial lining of mouth, nose, and anus

Skeletal system (bone and cartilage)

Epithelial lining of respiratory system

Cornea, retina, and lens of eye

Muscular system (skeletal and smooth muscle)

Epithelial lining of urethra, urinary bladder, and reproductive system

Nervous tissue (central and peripheral, melanoblasts)

Connective tissue, adipose

Liver

Sensory receptors in epidermis and epithelia of eye, ear, and nose

Urinary system

Pancreas

Adrenal medulla

Circulatory (cardiovascular and lymphatic) systems

Epithelial component of the thymus and tonsils

Tooth enamel

Reproductive system (gonads, ducts, accessory glands)

Thyroid and parathyroid glands

Epithelium of pineal and pituitary glands

Dermis of skin

Trachea, bronchi, lungs

Mammary glands

Adrenal cortex

Epithelial lining of the tympanic cavity and auditory tube

Inner ear

Hematopoietic system (spleen, blood cells)

Prostate

 

Tooth dentin

Pharynx

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Other ovarian germ cell tumors:

COMPARATIVE PATHOLOGY:

Ovarian Teratomas

Testicular Teratomas

Extragonadal Teratomas

REFERENCES:

  1. Bakthavatchalu V, Muthupalani S, Marini RP, Fox JG. Endocrinopathy and aging in ferrets.  Vet Pathol.  2016;53(2):349-365.
  2. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016: 3, 115-116, 251.
  3. Foster RA. Male genital system. In: Maxie MG, ed. Jubb Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:496.
  4. Foster RA. Male reproductive system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1210-1211.
  5. Foster RA. Female reproductive system and mammae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016: 1161.
  6. Fox JG, Muthupalani S, Kiupel M, Williams B. Neoplastic diseases.  In: In: Fox JG, Marini RP. Biology and diseases of the ferret.  3rd ed.  Ames, IA: Wiley; 2014: 595.
  7. Kegler K, Kroner B, Baumgartner W, Wohlsein P. Feline coccygeal teratoma: Immunohistochemical characterization of immature tissue components.  J Comp Path.  2014; 151:195-201.
  8. Leal de Araujo J, Perry A, Wild J, Kleinschmdit L, Hoppes S, Rech RR. Ovarian teratocarcinoma in an emu (Dromaius novaehollandiae): histopathological and immunohistochemical characterization.  Jour Comp Pathol.  2018;159:31-35.
  9. Machida Y, Michishita M, Wada M, et. al. Malignant oestrogen-producing teratoma in a cat.  Jour Comp Pathol. 2017;156:178-182.
  10. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:377-378.


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