JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-T02 (NP)

 

Signalment (JPC #1460187):  Rhesus macaque

HISTORY:  This animal was used in an experimental pulmonary research study.

HISTOPATHOLOGIC DESCRIPTION: Lung:  Multifocally, over 90% of alveolar septa,  are expanded by eosinophilic homogenous edema fluid, eosinophilic fibrillar material (fibrin), fibrosis, and few neutrophils, macrophages, lymphocytes, and plasma cells.  There is necrosis and loss of type I pneumocytes.  Multifocally and strikingly, alveoli are lined by cuboidal epithelial cells (type II pneumocyte hyperplasia), which occasionally form micropapillary projections into alveolar lumina.  Multifocally, alveolar lumina contain increased numbers of macrophages and fewer neutrophils mixed with edema, minimal hemorrhage, and fibrin.  Multiple contiguous alveoli coalesce and are expanded by clear space (emphysema), or are consolideated (atelectasis).  The bronchiolar epithelium is hyperplastic, piled up to 4 layers thick.  There is multifocal anthracosilicosis and perivascular, peribronchiolar and pleural edema and fibrin exudation.

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, interstitial, proliferative, subacute, diffuse, marked, with type II pneumocyte hyperplasia, alveolar emphysema and bronchiolar epithelial hyperplasia, Macaca mulatta, non-human primate.

ETIOLOGIC DIAGNOSIS:  Pulmonary oxygen toxicosis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Caswell JL, Williams KJ. Respiratory System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier; 2015:518.
  2. Husain AN. The lung. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, PA: Elsevier Saunders; 2009:680-682.
  3. Lowenstine LJ, Osborn KG. Respiratory system diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardiff S, Morris T, eds. Nonhuman Primates in Biomedical Research Volume 2: Diseases. 2nd ed. San Diego, CA: Academic Press; 2012:112-116.
  4. Mach WJ, Thimmesch AR, Pierce JT, Pierce JD. Consequences of hyperoxia and the toxicity of oxygen in the lung. Nurs Res Pract. 2011;Article ID 260482:7 pages.

 


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