JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2017
U-M13 (NP)

Signalment (JPC #1902445):  A nine-year-old Basenji dog

HISTORY:  This dog developed polyuria/polydipsia and two months later had 4+ glucosuria, normoglycemia and hypothyroidism (T4 =1.6).  Two months later the dog presented in renal failure.

HISTOPATHOLOGIC DESCRIPTION:  Kidney (2 sections):  Diffusely, the cortical and medullary interstitium is expanded by moderate amounts of fibrous connective tissue that surrounds, separates, and often replaces tubules and glomeruli and is admixed with moderate numbers of lymphocytes, plasma cells, and fewer macrophages that occasionally contain hemosiderin pigment.  Multifocally, tubules are atrophied, degenerate, necrotic, or lost.  Remaining tubules are often mildly ectatic and are either lined by attenuated epithelium with occasional luminal proteinosis or by epithelial cells with large, up to 15 um diameter, nuclei (karyomegalic cells), with finely stippled chromatin and abundant granular cytoplasm.  Within the medulla, tubular epithelium in multifocal to focally extensive areas, has shrunken pyknotic, karryorhectic nuclei and hypereosinophilic cytoplasm (necrosis) and cells are sloughed into tubule lumina; there is dilation or expansion of tubule lumina by granular eosinophilic debris or homogenous proteinacoues fluid (renal papillary necrosis).  Multifocally, there is global glomerulosclerosis, periglomerular fibrosis, and mild congestion.

MORPHOLOGIC DIAGNOSIS:  Kidney:  Fibrosis, interstitial, diffuse, moderate, with tubular degeneration and atrophy, multifocal lymphoplasmacytic nephritis, tubular epithelial cell karyomegaly, and papillary necrosis, Basenji, canine.

ETIOLOGIC DIAGNOSIS:  Hereditary tubular nephropathy

CONDITION:  Fanconi-like Syndrome

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

NOAH’S ARKIVE: (Canine): F09075

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

Other breed-related diseases of Basenjis:

REFERENCES:

  1. Breshears MA, Confer AW. The urinary system. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier;2016:653-654.
  2. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. 6th ed. Vol 2. Philadelphia, PA: Elsevier Saunders;2016:428-429.
  3. Darrigrand-Haag RA, Center SA, Randolph JF, Lewis RM, Wood PA. Congenital Fanconi syndrome associated with renal dysplasia in 2 Border Terriers.  J Vet Intern Med 1996;10(6):412-419.
  4. Deinhofer M. Paradoxic glucosuria (Fanconi syndrome) in a bull. Vet Rec 1996;138:395-396.
  5. Greco DS. Congenital and inherited renal disease of small animals. Vet Clinics of North Amer 2001;31(2):393-399.
  6. Hsu B, Wehrli S, Yandrasitz J, Fenstermacher E, Palmieri M, Rea C, McNamara P, Bovee K, Segal S. Renal brush border membrane lipid composition in Basenji dogs with spontaneous idiopathic Fanconi Syndrome. Metabolism 1994;43:1073-1078.
  7. Settles E, Schmidt D. Fanconi syndrome in a Labrador retriever. J Vet Intern Med 1994;8:390-393.


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