September 2018
D-M11 (NP)

Signalment (AFIP Accession # 2287584):  6-year-old female donkey

HISTORY:  1-week history of anorexia, depression, and weakness; in late gestation.  On PE: increased heart and respiration rates, dehydration, and dependent edema.  The serum was grossly lipemic.

HISTOPATHOLOGIC DESCRIPTION:  Liver:  Diffusely the hepatocytes are markedly enlarged by a discrete clear cytoplasmic vacuole (lipid) up to 20um in diameter that flattens and displaces the nucleus to the periphery (vacuolar degeneration, lipid type).  Multifocally, vacuoles of adjacent hepatocytes coalesce.  There are few hepatocytes that are shrunken, hypereosinophilic, and pyknotic (necrosis).  Diffusely, sinusoids are collapsed.  Multifocally, portal areas contain few lymphocytes and plasma cells, admixed with rare neutrophils.  The capsule is mildly thickened by fibrous connective tissue, and the liver has a rounded contour.

MORPHOLOGIC DIAGNOSIS:  Liver, hepatocytes:  Vacuolar change, lipid-type, diffuse, severe, breed unspecified, donkey (Equus asinus), equine.

CONDITION:  Hepatic lipidosis, hyperlipemia syndrome, equine hyperlipidemia, fatty liver disease










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