JPC SYSTEMIC PATHOLOGY

INTEGUMENT SYSTEM

November 2016

I-P08

 

Signalment (JPC #1754374):  A stray cat

HISTORY:  This cat had severe dermatitis of the ears, face, and forelegs.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin, pinna:  Up to 80 percent of the stratum corneum is expanded up to 4 mm by parakeratotic hyperkeratosis with numerous 300 um wide tunnels which contain many arthropods up to 250 x 150 um diameter, with a 4 um thick chitinous exoskeleton, dorsal spines, a hemocoele, striated muscle, jointed appendages, and reproductive organs.  There are rare, 60 um diameter eggs that contain basophilic globular material surrounded by a 5 um thick, tan, anisotropic shell.  There are multifocal intracorneal pustules containing degenerate neutrophils and necrotic debris.  Diffusely, scattered throughout the superficial dermis, surrounding blood vessels, and adnexa are moderate numbers of neutrophils, macrophages, eosinophils, fewer lymphocytes, and plasma cells.  The epidermis is moderately hyperplastic and characterized by deep anastomosing rete ridges and acanthosis with increased intracellular clear space (edema) and prominent intracellular bridging (spongiosus).  Apocrine glands are frequently dilated and lined by attenuated epithelium.     

MORPHOLOGIC DIAGNOSIS:  Haired skin, pinna:  Parakeratosis, diffuse, severe, with intracorneal pustules, neutrophilic and histiocytic dermatitis, and intracorneal arthropod parasites and eggs, etiology consistent with Notoedres cati, breed not specified, feline.

ETIOLOGIC DIAGNOSIS:  Epidermal notoedriasis

CAUSE:  Notoedres cati

CONDITION:  Notoedric mange

CONDITION SYNONYMS:  Feline scabies, head mange

GENERAL DISCUSSION:

LIFE CYCLE:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Histologic

Acariasis

Facial dermatitis

Gross

Other intensely pruritic skin diseases with predilection for face and ears:

COMPARATIVE PATHOLOGY:

References:

  1. Maudlin E, Peters-Kennedy J. Skin and appendages. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA; Elsevier Saunders; 2016:675.
  2. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat Clinical and Histopathologic Diagnosis. 2nd ed. Ames, IA:Blackwell Publishing Professional; 2005:219-220.
  3. Percy DH, Barthold SW. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing Professional; 2016:154, 191, 238, 303.
  4. Scott DW, Miller WH, Griffin CE. Muller & Kirk's Small Animal Dermatology. 7th ed. Philadelphia, PA: WB Saunders Company; 2013:80, 880.


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