January 2015

Signalment (AFIP #81-978):  Adult owl monkey (Aotus trivirgatus), gender unspecified

HISTORY:  This owl monkey had been maintained in a research laboratory.

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Diffusely there are changes at all levels of the nephron.  Glomeruli have one or more of the following changes: thickening of the mesangial matrix; thickening and hyalinization of  Bowman’s capsule; hypercellularity; hypertrophy of the parietal and visceral epithelium; thickening of the glomerular basement membrane; glomerulosclerosis (obsolescence); synechiae between the glomerulus and Bowman’s capsule; homogeneous brightly eosinophilic proteinaceous fluid within the uriniferous space and periglomerular fibrosis.  Multifocally, infiltrating the interstitium, surrounding, separating and replacing tubules and glomeruli are high numbers of lymphocytes, plasma cells and eosinophils.  Multifocally, tubules within areas of inflammation have one or more of the following changes: shrunken with attenuated epithelium and thickened basement membranes up to two times normal (atrophy); ectasia; homogeneous brightly eosinophilic intraluminal protein casts (proteinosis) and variable amounts of intraluminal sloughed epithelial cells, necrotic and cellular debris.  Multifocally, tubular epithelium is swollen with vacuolated cytoplasm (degeneration); has bright eosinophilic cytoplasm with a shrunken, pyknotic or absent nucleus (necrosis) or has amphophilic cytoplasm with a high nuclear to cytoplasmic ratio and piles up (regeneration).  Rarely, tubular epithelial cells contain intracytoplasmic golden-brown, granular pigment (bile or hemosiderin).  There is mild, diffuse interstitial medullary fibrosis.  Multifocally, the subcapsular surface is irregular and occasionally indented.

Kidney:  Periodic acid methenamine silver strain (PAMS stain):  Multifocally, there is thickening and reduplication of glomerular basement membranes

MORPHOLOGIC DIAGNOSIS:  Kidney:  Glomerulonephritis, membranoproliferative, chronic, multifocal, moderate, with glomerular obsolescence, lymphoplasmacytic and eosinophilic interstitial nephritis, tubular degeneration, atrophy, and proteinosis, owl monkey (Aotus trivirgatus), nonhuman primate.

CONDITION:  Glomerulonephritis (GN)











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