JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2015
U-M14

Signalment (AFIP #81-978):  Adult owl monkey (Aotus trivirgatus), gender unspecified

HISTORY:  This owl monkey had been maintained in a research laboratory.

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Diffusely there are changes at all levels of the nephron.  Glomeruli have one or more of the following changes: thickening of the mesangial matrix; thickening and hyalinization of  Bowman’s capsule; hypercellularity; hypertrophy of the parietal and visceral epithelium; thickening of the glomerular basement membrane; glomerulosclerosis (obsolescence); synechiae between the glomerulus and Bowman’s capsule; homogeneous brightly eosinophilic proteinaceous fluid within the uriniferous space and periglomerular fibrosis.  Multifocally, infiltrating the interstitium, surrounding, separating and replacing tubules and glomeruli are high numbers of lymphocytes, plasma cells and eosinophils.  Multifocally, tubules within areas of inflammation have one or more of the following changes: shrunken with attenuated epithelium and thickened basement membranes up to two times normal (atrophy); ectasia; homogeneous brightly eosinophilic intraluminal protein casts (proteinosis) and variable amounts of intraluminal sloughed epithelial cells, necrotic and cellular debris.  Multifocally, tubular epithelium is swollen with vacuolated cytoplasm (degeneration); has bright eosinophilic cytoplasm with a shrunken, pyknotic or absent nucleus (necrosis) or has amphophilic cytoplasm with a high nuclear to cytoplasmic ratio and piles up (regeneration).  Rarely, tubular epithelial cells contain intracytoplasmic golden-brown, granular pigment (bile or hemosiderin).  There is mild, diffuse interstitial medullary fibrosis.  Multifocally, the subcapsular surface is irregular and occasionally indented.

Kidney:  Periodic acid methenamine silver strain (PAMS stain):  Multifocally, there is thickening and reduplication of glomerular basement membranes

MORPHOLOGIC DIAGNOSIS:  Kidney:  Glomerulonephritis, membranoproliferative, chronic, multifocal, moderate, with glomerular obsolescence, lymphoplasmacytic and eosinophilic interstitial nephritis, tubular degeneration, atrophy, and proteinosis, owl monkey (Aotus trivirgatus), nonhuman primate.

CONDITION:  Glomerulonephritis (GN)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

References:

  1. Alpers CA, Chang A. The kidney. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015;899-927.
  2. Breshears MA, Confer AW. The urinary system. In: Zachary JF, ed. Pathological Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier Mosby; 2016:644-649.
  3. Chalifoux LV, Bronson RT, Sehgal P, Blake BJ, King NW. Nephritis and hemolytic anemia in owl monkeys (Aotus trivirgatus). Vet Pathol. 1981;18(Suppl. 6):23-37.
  4. Cianciolo RE, Mohr FC, Aresu L, et al. World Small Animal Veteinary Associatin Renal Pathology Initiative: Classification of Glomerular Diseases in Dogs. Vet Pathol. 2016 Jan;53(1):113-35.
  5. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:401-413.
  6. Cline JM, Brignolo, L, Ford EW. Urogenital system. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhunman Primates in Biomedical Research: Diseases. Vol 2. 2nd ed. San Diego, CA: Elsevier Inc.; 2012:489-491.
  7. Ersdal C, Jorgensen HJ, Lie KI. Acute and chronic Erysipelothrix rhusiopathiae infection in lambs. Vet Pathol. 2015;52(4):635-643.
  8. Gozalo A, Dagle GE, Montoya E, Weller RE, Malaga CA. Spontaneous cardiomyopathy and nephropathy in the owl monkey (Aotus sp.) in captivity. J Med Primatol. 1992;21(5):279-284.
  9. Hunt RD, Van Zwieten MJ, Baggs RB., et al. Glomerulonephritis in the owl monkey (Aotus trivirigatus). Lab Anim Sci. 1976;26(6):1088-1092.
  10. Jacoby RO, Fox JG, Davisson M. Biology and diseases of mice. In: Fox JG, Anderson LC, Loew FM, Quimby FW, ed. Laboratory Animal Medicine. 2nd ed. San Diego, CA: Academic Press;2002:109.
  11. King NW, Baggs RB, Hunt RD, Van Zwieten MJ, Mackey JJ. Glomerulonephritis in the owl monkey (Aotus trivirigatus): Ultrastructural observations. Lab Anim Sci: 1976;26(6):1093-1103.
  12. Krutak UA, Kubber-Heiss A, et al. Nephropathies in the European Captive Cheeetah (Acinonyx jubatus) Population. J Zoo Wildl Med. 2016;47(3):797-805.
  13. Nagatake T, Broderson JR, Tegoshi T, Collins WE, Aikawa M. Renal pathology in owl monkeys vaccinated with Plasmodium falciparum asexual blood-stage synthetic peptide antigens. Am J Trop Med Hyg. 1992;47(5):614-620.
  14. Naoaki Y, Nanako H, Junichi K, et al. Relationship Between Immunoglobulin Deposition and Early Lesions of Progressive Glomerulonephropathy in Young Common Marmosets. Vet Pathol. 2018; 55(1):173-6.
  15. Vezzali E, Manno RA, Salerno D, Oberto G, Nyska A, Ramot Y. Spontaneous glomerulonephritis in Göttingen minipigs. Toxicol Pathol. 2011;39(4):700-5.

 

 


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |