JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-M05

SIGNALMENT (JPC Accession # 1483487):  Southdown ewe

HISTORY:  Tissue from a Southdown ewe that had been kept out of the sunlight for three years because of a photosensitivity that developed shortly after weaning.

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Diffusely, there is marked cortical and medullary interstitial fibrosis which widely separates, surrounds and replaces approximately 50% of the tubules.  Multifocally, remaining tubules are either shrunken and atrophic or dilated up to 300 um in diameter (tubular ectasia), lined by attenuated epithelium, and contain a variable amount of brightly eosinophilic, homogenous protein (tubular proteinosis) and occasionally, sloughed epithelial cells.  Diffusely, tubular epithelial cells exhibit one or more of the following changes:  Hypertrophy with indistinct cell borders and microvacuolated cytoplasm (degeneration); shrunken with bright eosinophilic cytoplasm and a pyknotic to absent nucleus (necrosis); or a high nuclear to cytoplasmic ratio with amphophilic cytoplasm and a vesiculate nucleus with rare mitotic figures (regeneration).  Multifocally, tubular epithelial cells occasionally contain granular to globular yellow-brown pigment (bilirubin).  Multifocally, there are moderate numbers of lymphocytes, plasma cells, occasional macrophages, and reactive fibroblasts which infiltrate the interstitium.  Multifocally, glomeruli are surrounded by dense fibrous connective tissue (periglomerular fibrosis) and Bowman’s space is often lined by cuboidal, hyperplastic and hypertrophied epithelial cells, which rarely are adhered to Bowman’s capsule (synechia).  Multifocally in less than 25% of glomeruli  there is either global or segmental increase in mesangial cell density, mesangial cells are mildy hypertrophied, and there is moderate thickening of the basement membrane of Bowman’s capsule.). 

MORPHOLOGIC DIAGNOSIS:  Kidney:  Fibrosis, interstitial, diffuse, marked, with tubular ectasia, degeneration, necrosis, loss, regeneration and pigmentation, with interstitial lymphoplasmacytic nephritis, Southdown, ovine.

ETIOLOGIC DIAGNOSIS:  Inherited hyperbilirubinemic nephropathy

CONDITION:  Gilbert (pronounced “zheel-BAIR”) syndrome; congenital hyperbilirubinemia

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

References:

  1. Bain PJ. Liver. In: Latimer KS, ed. Duncan and Prasse’s Veterinary Laboratory Medicine Clinical Pathology. 5th ed. West Sussex, UK: Wiley-Blackwell; 2011:217-218.
  2. Brown DL, Van Wettere AJ, Cullen JM. Hepatobiliary System and Exocrine Pancreas. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier Mosby; 2017:424-425.
  3. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:430.
  4. Cullen JM, Stalker MJ. Liver and biliary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:293.
  5. Cuppage FE, Shimamura T, McGavin MD. Nephron obstruction in mutant Southdown sheep. Vet Pathol. 1979;16(4):483-485.
  6. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:579-580.
  7. McGavin MD, Cornelius CE, Gronwall RR. Lesions in Southdown sheep with hereditary hyperilirubinemia. Vet Pathol. 1972;9(2):142-151.
  8. Schulman FY, Montali RJ, Bush M, et al. Dubin-Johnson-like syndrome in golden lion tamarins (Leontopithecus rosalia rosalia). Vet Pathol. 30(6):491-498.
  9. Theise ND. Liver and gallbladder.In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:853-854.

 

 


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |