JPC SYSTEMIC PATHOLOGY
URINARY
JANUARY 2018
U-N01

Signalment U-N01a (JPC 1759231):  Pig

HISTORY:  Tissue from a large abdominal mass found incidentally at the time of slaughter of a market pig.

HISTOPATHOLOGIC DESCRIPTION:  Kidney (two sections):  Within the cortex, compressing adjacent renal parenchyma and extending to cut borders is an encapsulated, partially lobulated, well-demarcated, expansile neoplasm composed of a disorganized mixture of three distinct cell populations: epithelial, mesenchymal and blastemal.  The epithelial population is composed of cuboidal to columnar cells arranged in infolded tubules and occasionally projecting densely cellular tufts into lumina with cells lining a fibrovascular stalk (primitive glomeruli).  These neoplastic cells have variably distinct cell borders, a moderate amount of eosinophilic fibrillar to foamy cytoplasm, irregularly round to oval nuclei with densely clumped chromatin and 1-2 generally distinct nucleoli.  The mitotic rate is 2 per HPF.  The mesenchymal population is composed of spindle cells loosely arranged in vague streams (embryonal mesenchyme).  These neoplastic cells are stellate to spindle with variably distinct cell borders, a scant amount of eosinophilic fibrillar cytoplasm, oval to elongate nuclei with finely stippled chromatin and 1-2 variably distinct nucleoli.  The mitotic rate is <1 per HPF.  The blastemal population is composed of polygonal cells arranged in vague nests.  These neoplastic cells have indistinct cell borders, a scant amount of eosinophilic fibrillar cytoplasm and a high nuclear to cytoplasmic ratio.  Nuclei are irregularly round to oval with densely clumped chromatin and 1-3 variably distinct nucleoli.  The mitotic rate is 1 per HPF.  Multifocally there is scattered individual cell necrosis.  Multifocally there are small aggregates of lymphocytes and plasma cells, which extend into the adjacent cortical interstitium.  In the adjacent kidney there are multifocal areas of interstitial hemorrhage and tubular atrophy.

MORPHOLOGIC DIAGNOSIS:  Kidney:  Nephroblastoma, breed unspecified, porcine.

Signalment U-N01b (JPC 1923149):  Pigtailed macaque.

HISTORY:  Renal mass from a 6‑month‑old female pigtailed macaque.

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Within the cortex, compressing adjacent renal parenchyma and extending to cut borders is an encapsulated, well demarcated, lobulated, expansile neoplasm.  In one lobe, the neoplasm is composed of a disorganized mixture of three distinct cell populations: epithelial, mesenchymal and blastemal.  The epithelial population is composed of cuboidal to columnar cells arranged in infolded tubules and occasionally projecting tufts into lumina (primitive glomeruli).  These neoplastic cells have variably distinct cell borders, a moderate amount of eosinophilic fibrillar to foamy cytoplasm, irregularly round to oval nuclei with densely clumped chromatin and 1-2 generally distinct nucleoli.  The mitotic rate is 2 per HPF.  The mesenchymal population is composed of spindle cells loosely arranged in vague streams (embryonal mesenchyme).  These neoplastic cells are stellate to spindle with variably distinct cell borders, a scant amount of eosinophilic fibrillar cytoplasm, oval to elongate nuclei with finely stippled chromatin and 1-2 variably distinct nucleoli.  The mitotic rate is <1 per HPF.  The blastemal population is composed of polygonal cells arranged in vague nests.  These neoplastic cells have indistinct cell borders, a scant amount of eosinophilic fibrillar cytoplasm and a high nuclear to cytoplasmic ratio.  Nuclei are irregularly round to oval with densely clumped chromatin and indistinct nucleoli.  The mitotic rate is 1 per HPF.  The second lobe is composed of blastemal and mesenchymal cell populations.  The blastemal population is composed of polygonal cells arranged in vague nests, ribbons, and solidly cellular areas.  These neoplastic cells have indistinct borders, an abundant amount of eosinophilic to amphophilic, foamy to fibrillar cytoplasm, large, vesiculate nuclei with1-2 prominent nucleoli.  Mitotic rate is 5 per HPF.   There is moderate anisokaryosis and anisocytosis.  Separating and surrounding the blastemal population is the previously described mesenchymal population producing distinctive streams of eosinophilic to fibrillar matrix that surrounds and separates nests of neoplastic cells.  Multifocally there is individual cell necrosis and areas of coagulative and lytic necrosis.  Multifocally, there is minimal to moderate dilatation of tubules (ectatic tubules).

MORPHOLOGIC DIAGNOSIS:  Kidney:  Nephroblastoma, Pigtailed macaque (Macaca nemestrina), non-human primate.

ETIOLOGY: Unknown; Wilms’ tumor locus has been mapped at the chromosome 11p13 as a tumor suppressor gene.

SYNONYMS:  Wilms’ tumor, embryonal or renal adenosarcoma, and embryonal nephroma

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:

References:

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  3. Brewer DM, Cerda-Gonzalez S, Dewey CW, et al. Spinal cord nephroblastoma in dogs: 11 cases (1985-2007). J Am Vet Med Assoc. 2011;238(5):618-624.
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  9. Nair V, Fadly AM. Neoplastic diseases: Leukosis/sarcoma group. In: Swayne DE, ed. Diseases of Poultry. 13th ed. Ames, IA: Wiley-Blackwell Publishing; 2013:578-582.
  10. Rehulka J. Spontaneous nephroblastoma in a hatchery rainbow trout Oncorhynchuis mykiss. Disease of Aq Organ. 1992;14:75-79.
  11. Terrell SP, Platt SR, Chrisman CL, et al. Possible intraspinal metastasis of a canine spinal cord nephroblastoma. Vet Pathol. 2000;37:94-97.
  12. Traslavina RP, Aleman M, Affolter VK, et al. Pathology in practice. Spinal cord (ectopic) nephroblastoma in a dog. J Am Vet Med Assoc.  2013 Jun 15;242(12):1661-1663.
  13. Zoller M, Matz-Rensing K, Fabrion A, Kaup F. Malignant nephroblastoma in a common marmoset (Callithrix jacchus). Vet Pathol. 2008:45:80-84.

 


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