JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES
May 2018
S-N03 (NP)

Signalment (JPC Accession # 1421244):  Cat; age, gender and breed unspecified.

HISTORY:  This cat had an abnormal pupillary opening, and the eye was surgically removed.

HISTOPATHOLOGIC DESCRIPTION:  Eye:  Diffusely expanding and effacing all parts of the anterior uvea including the iris and infiltrating the ciliary body, filtration angle, scleral plexus, and limbus is an unencapsulated neoplasm composed of sheets of round cells separated by a fine fibrovascular stroma. The neoplastic cells have distinct borders, a scant amount of eosinophilic cytoplasm, an irregularly round nucleus with clumped chromatin and one variably distinct nucleolus. The mitotic rate averages 1 per HPF. There is mild anisokaryosis and anisocytosis. Neoplastic cells also infiltrate the ora ciliaris retinae, and unilaterally into the choroid, and are present in low numbers within the anterior, posterior, and vitreous chambers. Throughout the iris, limbus, and spaces of Fontana, lymphatics are mildly to moderately dilated (edema).

MORPHOLOGIC DIAGNOSIS:  Eye, uvea:  Lymphoma, breed unspecified, feline.

GENERAL DISCUSSION: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY

REFERENCES

  1. Cullen CL, Webb AA. Ocular manifestations of systemic disease. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:1949-1950, 2011, 2057, 2087.
  2. Dubielzig RR. Tumors of the eye. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2017:912-914.
  3. Fabijan J, Woolford L, Lathe S, Simmons G, Hemmatzadeh F, Trott DJ, Speight N. Lymphoma, koala retrovirus infection, and reproductive chlamydiosis in a koala (Phascolarctos cinereus). J Comp Path. 2017;157(2-3):188-192.
  4. Gilger BC. Equine ophthalmology. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:1574-5.
  5. Gould D, Papasoulitis K. Clinical microbiology and parasitology. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:308.
  6. Grahn BH, Peiffer RL Jr. Veterinary ophthalmic pathology. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:512-514.
  7. Hendrix DVH. Diseases and surgery of the canine anterior uvea. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:1183-1184.
  8. Ledbetter EC, Gilger BC Diseases and surgery of the canine cornea and sclera. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:1033.
  9. Narfström K, Petersen-Jones SM. Diseases of the canine ocular fundus. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:1376.
  10. Ojkic D, Brash ML, Jackwood MW, Shivaprasad HL. Viral diseases. In: Boulianne M, ed. Avian Disease Manual. 7th ed. Jacksonville, FL: American Association of Avian Pathologists, Inc.; 2013:30-38.
  11. Wilcock BP, Njaa BL. Special senses. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier; 2016:482. 


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