JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-M08

SIGNALMENT (JPC #1898566):  12-year-old female Pomeranian dog

HISTORY:  This dog exhibited anorexia, lethargy, reluctance to move, dyspnea, and had areas of ulceration on the tongue.

HISTOPATHOLOGIC DESCRIPTION:  Stomach, fundus: Diffusely affecting the superficial to deep layers of the gastric glands are areas of epithelial necrosis characterized by shrunken, individualized chief and parietal cells with pyknotic nuclei, admixed with cellular and karyorrhectic debris, degenerate neutrophils, fibrin, hemorrhage, fibrosis,and deposition of fine basophilic granular mineral (mineral), or mineralization of necrotic cells. Multifocally there are mucosal erosions and gastric glands contain necrotic debris, neutrophils, and are lined by attenuated epithelium. Vessels within the lamina propria and submucosa frequently contain organizing and recanalized thrombi, and there is vasculitis characterized by hypertrophy, necrosis and/or loss of endothelium within the tunica intima and disruption and thickening of the tunica media byedema, fibrin, few neutrophils, mineral, and necrotic debris. Multifocally the lamina propria and submucosa are expanded by neutrophils, macrophages, fewer lymphocytes, plasma cells and edema.

MORPHOLOGIC DIAGNOSIS:  Stomach, fundus: Parietal and chief cell necrosis, subacute, diffuse, moderate with chronic-active gastritis, mineralization, fibrosis, vasculitis and thrombosis, Pomeranian, canine.

ETIOLOGIC DIAGNOSIS:  Uremic gastritis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

 

TYPICAL GROSS FINDINGS:

Nonrenal lesions of uremia

Renal lesions of uremia

 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

 DIFFERENTIAL DIAGNOSIS:

For soft tissue mineralization:

COMPARATIVE PATHOLOGY:

 REFERENCES

  1. Breshears MA, Confer AW. The Urinary System. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017: 640-641.
  2. Cianciolo RE, Mohr FC. Urinary System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016: 384-387.
  3. Gelberg HB. Alimentary system and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017: 365
  4. McLeland SM, Lunn KF, Duncan CG, Refsal KR, Quimby JM. Relationship among serum creatinine, serum gastrin, calcium-phosphorus product and uremic gastropathy in cats with chronic kidney disease. J Vet Intern Med. 2014; 28:827-837.
  5. Tripathi NK, Gregory CR, Latimer KS. Urinary System. In: Latimer KS, ed. Duncan and Prasse’s Veterinary Laboratory Medicine Clinical Pathology. 5th ed. Ames, IA: Wiley-Blackwell; 2011:280.
  6. Uzal FA, Plattner BL, Hostetter JM. Alimentary System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016: 16-17, 51.


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