JPC SYSTEMIC PATHOLOGY

PULMONARY SYSTEM

October 2017

P-V13

 

Signalment (JPC # 1619887): Three-week-old pig, breed and gender unspecified

HISTORY: This pig died after developing upper respiratory distress. At necropsy, there was a fibrinonecrotic membrane lining the nasal sinuses

HISTOPATHOLOGIC DESCRIPTION: Nasal turbinate: Diffusely, the subepithelial connective tissue is thickened up to 1 mm by many infiltrating lymphocytes, plasma cells, and fewer macrophages which infiltrate to the level of the turbinate bones multifocally. Diffusely, the respiratory epithelium is ulcerated or attenuated, and multifocally undergoes squamous metaplasia and there are small amounts of fibrin and hemorrhage adhered to the mucosa. Nasal mucous gland epithelial cells are often enlarged up to 50 um in diameter (cytomegaly) with abundant, often vesiculate cytoplasm and a single 20-30um, basophilic, irregular, smudgy to granular intranuclear viral inclusions that fills and distends the karyomegalic nucleus. Multifocally, the mucous glands are ectatic, lined by attenuated, degenerate and/or necrotic epithelium, and gland lumina contain viable and degenerate neutrophils admixed with variable amounts of amphophilic mucus and necrotic cellular debris. The nasal cavity is partially filled with an exudate composed of hemorrhage and sloughed and necrotic epithelial cells. Multifocally, the vascular endothelium is hypertrophic (reactive), and perivascular connective tissue is edematous with dilated lymphatics.  There are multifocal areas of mild turbinate bone resorption and remodeling.

MORPHOLOGIC DIAGNOSIS: Nasal turbinate: Rhinitis, lymphoplasmacytic and necrotizing, subacute, diffuse, marked, with mucosal ulceration, glandular epithelial karyomegaly, cytomegaly, and intranuclear viral inclusions, breed unspecified, porcine

ETIOLOGIC DIAGNOSIS: Cytomegaloviral Rhinitis

CAUSE: Suid Herpesvirus 2 (Cytomegalovirus)

CONDITION: Inclusion Body Rhinitis

GENERAL DISSCUSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS: 

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY: 

References: 

  1. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. New York, NY:Elsevier Limited; 2016:529-530.
  2. Lopez A. Respiratory system, mediastinum, and pleura. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby; 2017:491-492.
  3. Knowles DP. Herpesvirales. In: MacLachlan NJ, Dubovi EJ, eds. Fenner’s Veterinary Virology. 4th ed. San Diego, CA:Academic Press; 2011:195-6.
  4. Vitosh-Sillman SJ, Brodersen BW, et al. Pathology in practice. J Am Vet Med Assoc. 2017; 250(3):293-295.
  5. Yoon KJ, Edington N. Porcine cytomegalovirus. In: Straw BE, et al, eds. Diseases of Swine. 9th ed. Ames, IA:Blackwell Publishing; 2006:323-329.

 

 


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