JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

August 2017

P-B08

 

Signalment (JPC# 1795578): A horse

HISTORY: This animal had purulent nasal discharge and a chronic cough. The nasal mucosa and skin were ulcerated, and there was thickening of the superficial lymphatics and abscesses in the superficial lymph nodes.

HISTOPATHOLOGIC DESCRIPTION: Lung: Effecting  20% of the section there are multifocal, random,  variably sized nodules of pyogranulomatous inflammation with a central area of eosinophilic cellular and karyorrhectic debris and hemorrhage (necrosis), surrounded by viable and degenerate neutrophils, macrophages, lymphocytes, plasma cells, and rare multinucleated giant macrophages.  Inflammatory cells often extend into adjacent, congested alveolar septa and alveoli where they are admixed with homogenous eosinophilic material (edema), polymerized fibrin, necrotic debris and hemorrhage.  Multifocally, there are peribronchiolar and perivascular aggregates of lymphocytes, plasma cells, fewer macrophages, rare neutrophils and edema. The pleural and underlying subpleural connective tissue is expanded up to 0.5mm by edema, fibrin, graunulation tissue, and low numbers of previously described inflammatory cells.

MORPHOLOGIC DIAGNOSIS: Lung: Pneumonia, pyogranulomatous and necrotizing, multifocal, random, moderate, with hemorrhage, and pleural edema, breed unspecified, equine.

ETIOLOGIC DIAGNOSIS: Burkholderial pneumonia

CAUSE: Burkholderia mallei (formerly Pseudomonas mallei)

CONDITION: Glanders (Farcy for cutaneous disease)

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

ACUTE FORM:

CHRONIC FORM:

TYPICAL GROSS FINDINGS: 

ACUTE FORM: 

CHRONIC FORM: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ACUTE FORM:

CHRONIC FORM:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

Cutaneous form (Farcy):

Pulmonary form:

COMPARATIVE PATHOLOGY: 

References:

  1. Gilad J. Burkholderia mallei and Burkholderia pseudomallei: The causative micro-organisms of glanders and melioidosis. Recent Patents Anti-Infect Drug Disc. 2007; 2(3):233-241.
  2. Hunt RD, Jones TC, King NW. Veterinary Pathology. 6th ed., Baltimore, MD: Williams and Wilkins; 1997:450-451.
  3. Caswell JL, Williams KJ. Respiratory system. In: Maxie ME, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier; 2016:573.
  4. Laroucau K, Colaneri C, Jay M, Corde Y, drapeau A, Durand B, Zientara S, Beck C. Interlaboratory ring trial to evaluate CFT proficiency of European laboratories for diagnosis of glanders in equids. Vet Rec. 2016;178(25). doi: 10.1136/vr.103617; Accessed July 13, 2015.
  5. Lopez A, Martinson SA. Respiratory system, mediastinum and pleurae. In: Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby; 2016:177-179, 489-490.
  6. Radostits OM, Gay CC, Blood DC, Hinchcliff KW. Veterinary Medicine. 10th ed., London, England: Harcourt Publishers; 2007:1083-1085.
  7. Stundick MV, Albrecht AT, Houchens CR, Pierce Smith A, Dreier TM, Larsen JC. Animal Models for Francisella tularensis and Burkhoderia Species: Scientificc and Regulatory Gaps Toward Approval of Antibiotics Under the FDA Animal Rule, Vet Pathol. 2013 Sep;50(5):877-92.
  8. US Animal Health Assn: Glanders. In: Foreign Animal Diseases. 7th ed., Boca Raton, FL: Boca Publications Group, Inc.; 2008:281-286.
  9. Wernery U, Wernery R, Joseph M, Al-Salloom F, Johnson B, Kinne J, et al. Natural Burkholderia mallei infection in dromedary, Bahrain. Emerg Infect Dis 2011;17(7). http://dx.doi.org/10.3201/eid1707.110222. Accessed August 25, 2014.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |