JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

September 2016

I-M30

 

Signalment (JPC # 2327342):  2-year-old male blue Doberman pinscher

HISTORY:  This dog had a history of chronic keratoconjunctivitis and bilaterally symmetrical hair loss.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin: Diffusely, hair follicles are moderately distended by lamellations of keratin which occasionally entrap small clumps of dark brown granular to globular pigment (melanin), are variably distorted in shape (follicular dysplasia), and often contain fragmented hair shafts. Multifocally, melanocytes within the epidermis, the follicular epithelium, and in the perifollicular dermis are engorged with small clumps of melanin. In the superficial and deep dermis, adjacent to hair shafts and bulbs, as well as in the panniculus carnosus, are moderate numbers of melanin-containing macrophages (pigmentary incontinence) and aggregates and clumps of free melanin. The follicular epithelium is diffusely hyperkeratotic. The overlying epidermis is multifocally mildly hyperplastic characterized by mild thickening of the stratum spinosum (acanthosis).

MORPHOLOGIC DIAGNOSIS:  Haired skin: Follicular dysplasia, diffuse, moderate, with intrafollicular and intraepidermal melanin clumping, pigmentary incontinence, and hyperkeratosis, Doberman pinscher, canine.

CONDITION: Color dilution alopecia

SYNONYMS: Color mutant alopecia; blue dog disease

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat. 2nd ed. Oxford, England: Blackwell Science; 2005:518-522.
  2. Mauldin E, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA:Elsevier; 2016:539-541.
  3. Medleau L, Hnilica KA. Small Animal Dermatology, A Color Atlas and Therapeutic Guide. 2nd ed.   Louis, MO:Elsevier Inc; 2006:253-254.
  4. Parego R, Proverbio D, Roccabianca P, Spada E. Color dilution alopecia in a blue Doberman pinscher crossbreed. Can Vet J. 2009:50(5):511-14.
  5. Scott DW, Miller WH, Griffin CE. Muller & Kirk’s Small Animal Dermatology. 6th ed. Philadelphia, PA :WB Saunders Co; 2001:966-970.


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