JPC SYSTEMIC PATHOLOGY
ENDOCRINE SYSTEM
February 2019
E-N11

Signalment (JPC #1965139):  11-year-old castrated male German shorthair pointer

HISTORY:  None provided

HISTOPATHOLOGIC DESCRIPTION:  Slide A: Fibroadipose tissue: Extending to all borders and compressing adjacent adipose tissue is a multilobular, densely cellular, infiltrative neoplasm composed of polygonal cells arranged in nests and packets supported by a thin rim of sustentacular cells and a fine fibrovascular stroma, with lobules separated by dense bands of fibrovascular connective tissue.  Neoplastic cells have variably distinct borders, a moderate amount of pale eosinophilic, frequently vacuolated, granular cytoplasm, and round nuclei with stippled chromatin and 1-2 variably distinct nucleoli. There is moderate anisocytosis and anisokaryosis, with occasional neoplastic cells having large, multilobed nuclei (ancient change). Mitoses average 1 per 10 HPF. There are scattered areas of necrosis characterized by loss of tissue architecture and replacement by eosinophilic cellular and karyorrhectic debris, and individual cell necrosis characterized by hypereosinophilic cytoplasm, pyknosis, karyorrhexis and karyolysis, with variably sized foci of mineralization and acicular (cholesterol) cleft formation. Multifocally neoplastic cells impinge on vessel walls. There are multifocal peripheral infiltrates of lymphocytes, plasma cells, macrophages (often hemosiderin-laden), scattered hemorrhage, congestion, and accumulations of hematoidin pigment.

Slide B (Churukian-Schenk):  The cytoplasm of neoplastic cells contains many discrete, brown to black, argyrophilic granules.

MORPHOLOGIC DIAGNOSIS:  Fibroadipose tissue:  Chemodectoma, German shorthair pointer, canine.

SYNONYMS:  Aortic/carotid body tumor, paraganglioma, nonchromaffin paraganglionoma, extra-adrenal paraganglionoma, glomus cell tumor

GENERAL DISCUSSION:

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS: 

For gross finding of heart base tumor:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Holt DE, Henthorn P, Howell VM, Robinson BG, Benn DE. Succinate dehydrogenase subunit D and succinate dehydrogenase subunit B mutation analysis in canine pheochromacytoma and paraglanglioma. J Comp Path 2014; 151:25-34.
  2. Miller LM, Gal A. Cardiovascular system and lymphatic vessels. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:592.
  3. Miller MA. Endocrine system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:692.
  4. Romanucci M, Malatesta D. Cytological, histological and ultrastructural nuclear features of monster cells in canine carotid body carcinoma. J Comp Path. 2014; 151:57-62.
  5. Rosol T, Grone A. Endocrine glands. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:354-356.
  6. Yamamoto S, Fukushima R. Histopathological and Immunohistochemical evaluation of malignant potential in canine aortic body tumours. J Comp Path. 2013; 149:182-191.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |