JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

November 2016

I-T01

 

Signalment (JPC #1757055):  A dog

HISTORY:  None provided

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  There is a focally extensive area of epidermal and follicular hyperplasia with acanthosis, intercellular clear space with prominent intercellular bridging (spongiosis), multifocal intracellular edema, and moderate epidermal parakeratotic hyperkeratosis.  Diffusely within both the epidermis and follicular epithelium, the stratum granulosum is thin and lacks keratohyaline granules (hypogranulosis).  Multifocally, there are intracorneal pustules containing numerous degenerate neutrophils and necrotic debris.  Follicles often lack hair shafts, are moderately ectatic and plugged by lamellations of parakeratotic keratin (comedones).  There are numerous perifollicular viable and degenerate neutrophils, plasma cells, and fewer lymphocytes and macrophages that occasionally infiltrate (mural and luminal folliculitis) or efface (furunculosis) follicular walls. 

MORPHOLOGIC DIAGNOSIS:  Haired skin:  Hyperkeratosis, parakeratotic, focally extensive, moderate, with epidermal and follicular epithelial hyperplasia, neutrophilic and lymphohistiocytic perifollicular dermatitis and furunculosis, and intracorneal pustules, breed unspecified, canine.

ETIOLOGIC DIAGNOSIS:  Cutaneous thallotoxicosis

CAUSE:  Thallium toxicosis

GENERAL:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:  For detection of thallium:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Jones TC, Hunt RD, King NW. Veterinary Pathology. 6th ed. Baltimore, MD: Williams and Wilkins; 1997:745-747.
  2. Klaassen CD. Casarett and Doull"s Toxicology: The Basic Science of Poisons. 6th ed. New York, NY: McGraw-Hill; 2001:855-856.
  3. Maudlin EA, Peters-Kennedy J. Skin and appendages. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:568-569.
  4. Muhammad F, Riviere JE. Dermal toxicity. In: Gupta RC, ed. Veterinary Toxicology Basic and Clinical Principles. New York, NY: Elsevier; 2007: 271-272.
  5. Osweiler GD, Carson TL, Buck WB, Van Gelder GA. Clinical and Diagnostic Veterinary Toxicology. 3rd ed. Dubuque, IA: Kendall/Hunt Publishing Co; 1985:349-351.
  6. Puschner B, Basso MM, Graham TW. Thallium toxicosis in a dog consequent to ingestion of Mycoplasma agar plates. J Vet Diagn Invest. 2012; 24(1): 227-230.
  7. Scott DW, Miller WH, Griffin CE. Muller and Kirk"s Small Animal Dermatology. 7th ed. Philadelphia, PA: W.B. Saunders Co; 2013:671-673.
  8. Volmer, PA, Merola V, Osborne T, Bailey KL, Meerdink G.  Thallium toxiciosis in a pit bull terrier. J Vet Diagn Invest. 2006;18:134-137.


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