JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-N07

Signalment (JPC accession #2368962):  11-year-old bichon frise

HISTORY:  This dog presented with a sudden onset of profuse, hemorrhagic diarrhea.  A cecal mass was removed during surgery.

HISTOPATHOLOGIC DESCRIPTION: Cecum (per contributor): Originating in the tunica muscularis, expanding the muscular layers, and compressing the lumen of the cecum, is an unencapsulated, well demarcated, multilobular, 13mm diameter, densely cellular neoplasm composed of polygonal cells arranged in small, closely packed nests and packets separated by a fine, fibrovascular stroma.  Neoplastic have distinct borders and abundant lightly eosinophilic to clear and occasionally granular cytoplasm.  Nuclei are round with finely stippled chromatin and 1-2 indistinct nucleoli.  Mitotic figures average 2 per 10 HPF.  Multifocally, neoplastic cells are widely separated by  variably sized aggregates of clear, acicular clefts (cholesterol), surrounded by low numbers of macrophages, multinucleated giant cells, lymphocytes, and plasma cells further separated by clear space and ectatic lymphatics (edema), fibrin, minimal hemorrhage and occasional hemosiderin-laden macrophages.  Neoplastic lobules are separated by multifocal to focally extensive areas of edema, fibrosis, and hemorrhage, as well as numerous large dilated or congested vessels.

MORPHOLOGIC DIAGNOSIS:  Cecum:  Gastrointestinal neuroendocrine carcinoma (carcinoid), bichon frise, canine.

GENERAL DISCUSSION:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

 ADDITIONAL DIAGNOSTIC TESTS:

 DIFFERENTIAL DIAGNOSIS: (for histologic findings)  

 COMPARATIVE PATHOLOGY:

 References:

  1. Cullen JM, Stalker MJ. Liver and biliary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:349.
  2. Head KW, Cullen JM, Dubielzig RR, Else RW, Misdorp W, Patnaik AK, Tateyama S, van der Gaag I. Tumors of the Alimentary System of Domestic Animals, 2nd series.Washington D.C.: Armed Forces Institute of Pathology; 2003:33, 79, 94-96,127-128.
  3. Lowden LR, Davies JL. Malignant Neuroendocrine Tumor (Carcinoid) of the Spleen in an African Pygmy Hedgehog (Atelerix albiventris). J Comp. Path. 2016:155:88-91.
  4. Michishita M, Takagi M, Kishimoto TE, et al. Pancreatic neuroendocrine carcinoma with exocrine differentiation in a young cat. J Vet Diagn Invest. 2017:29(3):325-330.
  5. Michishita M, Takahashi K, Moriya H, Nakamura S, Koyama H, Sako T. Poorly differentiated rectal carcinoid in a cow. Vet Pathol.  2007;44:414-417.
  6. Munday JS, Lohr CV, Kiupel M. Tumors of the Alimentary Tract. In: Meuten J, ed. Tumors in Domestic Animals. 5th ed. Ames, Iowa: John Wiley & Soncs, Inc; 2017:559,568.
  7. Nakahira R, Michishita M, Yoshimura H, Hatakeyama H, Takahashi K. Neuroendocrine carcinoma of the mammary gland in a dog. J Comp. Path. 2015:152:188-191.
  8. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:105-106.


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