September 2016



Signalment (JPC #2839300):  5-month-old male castrated crossbred Sus scrofa (domestic swine)

HISTORY:  This animal was one of two affected in a group of 1000.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin and subcutis:  Multifocally, in the dermis and subcutis there is necrotizing vasculitis with transmural infiltration of vessel walls by moderate numbers of neutrophils, fewer macrophages and eosinophils, eosinophilic cellular and karyorrhectic debris, hemorrhage, and fibrin.  The inflammatory infiltrate and fibrin often extend into the surrounding dermis and subcutis.  There is perivascular and periadnexal edema.  There are overlying epidermal infarcts characterized by keratinocytes within all layers that have retention of cellular architecture but loss of differential staining and pyknotic nuclei (coagulative necrosis).  Hair follicles in affected areas are similarly necrotic. In the less affected epidermis, there is mild epidermal hyperplasia and mild orthokeratotic hyperkeratosis with anastomosing rete ridges.  Apocrine glands are moderately ectatic.

Kidney:  Diffusely, there is segmental to global necrotizing glomerulitis characterized by disruption of glomerular tufts and replacement by numerous viable and degenerate neutrophils, necrotic debris, and abundant fibrin that extend into and fill Bowman"s space; there are frequent fibrin thrombi within glomerular capillaries.  Occasionally, there is periglomerular hemorrhage and multifocally the parietal and visceral epithelium of Bowman’s capsule is fused (synechia).  There is necrotizing vasculitis of the arcuate vessels with hemorrhage, fibrin, and mild perivascular edema.  Neutrophils, lymphocytes and macrophages expand the interstitium, separate and surround tubules.  Multifocally, tubules are mildly ectatic and are often lined by attenuated epithelium and occasionally filled with an eosinophilic homogenous fluid (proteinosis), cellular debris (cellular casts), or rarely, degenerate neutrophils.  Tubular epithelial cells are swollen and contain numerous, variably sized amphophilic vacuoles (degeneration).

MORPHOLOGIC DIAGNOSES:  1. Haired skin and subcutis:  Vasculitis, necrotizing, neutrophilic, acute, multifocal, severe, with epidermal infarcts, crossbred swine, porcine. 2. Kidney: Glomerulitis and vasculitis, fibrinonecrotizing, neutrophilic, acute, diffuse, severe with fibrin thrombi, tubular degeneration, proteinosis, and cellular casts. 

CONDITION:  Porcine dermatitis and nephropathy syndrome (PDNS)










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