JPC SYSTEMIC PATHOLOGY
CARDIOVASCULAR SYSTEM
April 2019
C-M08 (NP)

Signalment (JPC #2417289):  One week-old holstein calf

HISTORY:  This calf was clinically normal and sacrificed for the collection of cardiac tissue for experimental purposes. 

HISTOPATHOLOGIC DESCRIPTION:  Heart:  Subjacent to the endocardium, extending into the myocardium, and within one of the papillary muscles are two expansile, unencapsulated, well demarcated masses up to 0.75 cm x 1.5 cm that separate, surround, isolate and replace individual cardiomyocytes and Purkinje fibers.  The masses are composed of multiple variably sized acini and tubules that measure up to 2.5 mm diameter and are lined by one to multiple layers of squamous to cuboidal epithelium with scant amount of eosinophilic cytoplasm, round to oval nuclei with no mitoses or atypia.  Between the tubules, there are multifocal small nests of similar epithelial cells and abundant collagenous connective tissue.  The interstitial tissue subjacent to the endocardium is mildly separated by clear space (edema).

MORPHOLOGIC DIAGNOSIS:  Heart, myocardium:  Epithelial inclusions, multifocal, holstein, bovine.

CONDITION:  Myocardial epithelial inclusions

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Alison RH, Elwell MR, Jokinen MP, Dittrich KL, Boorman GA. Morphology and classification of 96 primary cardiac neoplasms in Fischer 344 rats. Vet Pathol. 1987;24:488-494.
  2. Baker DC, Schmidt SP, Langheinrich KA, Cannon L, Smart RA. Bovine myocardial epithelial inclusions. Vet Pathol. 1992;30:82-88.
  3. Novilla MN, Sandusky GE, Hoover DM, Ray SE, Wightman KA. A retrospective survey of endocardial proliferative lesions in rats. Vet Pathol; 1991;28:156-165.
  4. Robinson WF, Robinson NA. The cardiovascular system. In: Maxie MG, ed Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier; 2016:22.
  5. Tursi M, Martinetti M, Gili S, et al. Myocardial adenomatoid tumor in eight cattle: evidence for mesothelial origin of bovine myocardial epithelial inclusions. Vet Pathol. 2009; 46:897-903.


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