JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-B02

Signalment (JPC #1454646):  A 13-year-old female dog

HISTORY:  This dog presented with a distended abdomen.

HISTOPATHOLOGIC DESCRIPTION:  Uterus:  The uterine wall is circumferentially thinned secondary to marked luminal dilation.  Diffusely filling the lumen, infiltrating the ulcerated endometrium and underlying uterine stroma and separating, surrounding and filling endometrial glands are many viable and degenerate neutrophils, fewer epithelioid macrophages, lymphocytes, plasma cells, hemorrhage, fibrin and eosinophilic cellular and karyrorrhectic debris (necrosis).  Endometrial glands are often ectatic and lined by attenuated to cuboidal epithelium or, occasionally, by tall columnar, pseudostratified epithelium which contains abundant eosinophilic foamy cytoplasm and vesiculate nuclei (progestational epithelium).  Multifocally, glandular epithelium is disrupted and replaced by eosinophilic cellular and karyorrhectic debris (necrosis) and fibrin.  Endometrial lymphatics are ectatic (edema) and blood vessels are congested.  The deep endometrial stroma is edematous and contains moderate numbers of large foamy macrophages.

MORPHOLOGIC DIAGNOSIS:  Uterus:  Endometritis, necrosuppurative, diffuse, moderate, with ectatic glands, breed unspecified, canine.

ETIOLOGY:  Bacterial infection of progesterone-primed endometrium

ETIOLOGIC DIAGNOSIS:  Bacterial endometritis

CONDITION:  Pyometra

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS: 

For an enlarged uterus:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Cline JM, Brignolo L, Ford EW. Rogenital System. In: Abee CR, Mansfield K, Tardif S, et al. Nonhuman primates in biomedical research: Vol 2.  San Diego, CA: Academic Press; 2012:514-515.
  2. De Biase D, Costagliola A, Del Piero F, et al. Coxiella burnetti in Infertile Dairy Cattle With Chronic Endometritis. Vet Pathol. 2018;55(4):539-542.
  3. Edwards J, Lassala AL, Spencer TE. Staphylococcus-associated abortions in ewes with long-term central venous catheterization. Vet Pathol. 2008;45(6):881-888.
  4. Egan RJ. Re: “Coxiella burnetti in Infertile Dairy Cattle With Chronic Endometritis”. Vet Pathol. 2018 Dec 17:300985818819231. doi: 10.1177/0300985818819231. [Epub ahead of print]
  5. Foster RA. Female Reproductive System and Mammae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1163-1164.
  6. Gibson A, Dean R, Yates D, Stavisky J. A retrospective study of pyometra at five RSPCA hospitals in the UK: 1728 cases from 2006 to 2011. Vet Rec. 2013;173(16):396.
  7. Klainbart S, Ranen E, Glikman G, Kelmer E, Bdolah-Abram T, Aroch I. Hindlimb lameness and gait abnormalities in bitches with pyometra. Vet Rec. 2014;175(2):46.
  8. Marino G, Barna A, Rizzo S, Zanghi A, Catone G. Endometrial polyps in the bitch: a retrospective study of 21 cases. J Comp Pathol. 2013;149(4):410-416.
  9. Moresco A, Munson L, Gardner IA. Naturally occurring and melengestrol acetate-associated reproductive tract lesions in zoo canids. Vet Pathol. 2009;46(6):1117-1128.
  10. Schlafer DH, Foster RA. Female Genital System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St Louis, MO: Elsevier; 2016: 387-393.
  11. Zhao JL, Ding YX, Zhao HX, et al. Presence of superantigen genes and antimicrobial resistance in Staphylococcus isolates obtained from the uteri of dairy cows with clinical endometritis. Vet Rec. 2014;175(14):352.


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