August 2018

SIGNALMENT (JPC #2329499):  A 3-month-old male Yorkshire crossbred feeder pig

HISTORY:  Eight pigs died acutely in a pen of 50 pigs which were experiencing bloody diarrhea, dehydration and weight loss which was refractory to antibiotic therapy.

HISTOPATHOLOGIC DESCRIPTION:  Colon:  There are multifocal to coalescing areas of hemorrhage and necrosis (lytic and coagulative) of superficial mucosal epithelium admixed with thin mat of fibrin, cellular and karyorrhectic debris, degenerate neutrophils, and colonies of basophilic bacteria.  Coagulative necrosis multifocally extends into crypts and is characterized by retention of architecture with more brightly eosinophilic cytoplasm of enterocytes.  Crypts are diffusely elongated up to 2-3 times normal, mutlifocally ectatic, containing an amphophilic to pale basophilic fibrillary material (mucus) (crypt hyperplasia).  Multifocally, crypts also contain hyperplastic goblet cells, and occasionally are ectatic and contain mucus, neutrophils and necrotic cellular debris (crypt abscess)  Blood vessels within the lamina propria, submucosa, and mesentery are congested, and multifocally, small vessels within the mucosa and submucosa contain a fibrillar to finely granular to hyalinized eosinophilic material (fibrin thrombi).  There are multiple ectactic, mucus filled crypts located within a Peyer’s patch (focal crypt herniation).

MORPHOLOGIC DIAGNOSIS:  Colon:  Colitis, necrohemorrhagic, acute, diffuse, moderate, with crypt and goblet cell hyperplasia and fibrin thrombi, Yorkshire cross (Sus scrofa domestica), porcine.

ETIOLOGIC DIAGNOSIS:  Brachyspiral colitis

CAUSE:  Brachyspira hyodysenteriae

CONDITION:  Swine dysentery

SYNONYMS:  Vibriotic dysentery, bloody scours, bloody dysentery, black scours, mucohemorrhagic diarrhea








DIFFERENTIAL DIAGNOSIS:  (bloody diarrhea in swine)



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