JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

November 2016

I-V16

 

Signalment (JPC #2593663):  An adult male cynomolgus monkey (Macaca fascicularis)

HISTORY:  This monkey developed generalized, acute, multifocal to coalescing, erythematous and vesicular skin lesions and died.

MICROSCOPIC DESCRIPTION:  Mucocutaneous junction, lip:  Multifocally, expanding and disrupting the hyperplastic epithelium of the oral mucosa are multiple vesicles that contain enlarged, pale, sloughed epithelial cells that often form syncytial cells with up to 10 nuclei and multifocal eosinophilic intranuclear viral inclusion bodies that measure up to 15um and are surrounded by a clear halo with peripheralized chromatin.  These cells are often individualized and are admixed with low numbers of neutrophils and pale flocculent eosinophilic material.  Within the surrounding epithelium, cells are discohesive, often exhibit intracellular edema (hydropic degeneration), and often form similar syncytial cells with intranuclear viral inclusions.  There is an ulcerated vesicle with similar sloughed cells, syncytial cells with intranuclear inclusions and flocculent material within the adjacent epidermis.  Intranuclear viral inclusion bodies are also present within the subjacent sebaceous glands.  There is hyperplasia of the mucosal epithelium and (to a lesser degree) the epidermis, with prominent rete ridges and spongiosis.  Multifocally within both the superficial subepithelial connective tissue and dermis are areas of hemorrhage admixed with few neutrophils and few moderately ectatic lymphatics (edema).  Multifocally, separating, surrounding, and occasionally replacing labial glands are moderate numbers of plasma cells, fewer Mott cells, occasional lymphocytes, macrophages, and rare neutrophils.

MORPHOLOGIC DIAGNOSIS:  Mucocutaneous junction:  Cheilitis, vesicular, multifocal, moderate, with viral syncytia, eosinophilic intranuclear viral inclusion bodies, epithelial hyperplasia, and mild lymphoplasmacytic hidradenitis, cynomolgus monkey (Macaca fascicularis), primate. 

ETIOLOGIC DIAGNOSIS:  Herpesviral dermatitis and cheilitis

CAUSE:  Simian varicella virus (Cercopithecine herpesvirus 9)

ETIOLOGY SYNONYMS:  Delta herpes, Liverpool vervet virus, patas herpesvirus, medical lake macaque virus

CONDITION:  Simian varicella

GENERAL: 

PATHOGENESIS: 

CLINICAL SIGNS:

TYPICAL GROSS FINDINGS: 

TYPICAL MICROSCOPIC FINDINGS: 

ULTRASTRUCTURE: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:

REFERENCES: 

  1. Bailey C, Mansfield K. Emerging and reemerging infectious diseases of nonhuman primates in the laboratory setting.  Vet Pathol. 2010;47:462-481.
  2. Gray GL. Simian varicella in old world monkeys. Comp Med. 2008;58:22-30.
  3. Jones TC, Hunt RC, King NW. Diseases Caused by Viruses. In: Veterinary Pathology, 6th ed. Baltimore, MD: Williams & Wilkins; 1997:222-223.
  4. MacLachlan NJ, Dubovi EJ. Herpesvirales. In: Fenner’s Veterinary Virology. 4th ed. San Diego, CA: Elsevier, Inc.; 2011:188.
  5. Murphy HW. Great apes. In: Miller RE, Fowler ME, ed. Fowler’s Zoo and Wild Animal Medicine. Vol 8. Louis, MO: Elsevier Saunders; 2015: 348.
  6. Ouwendijk WJD, Verjans GMGM. Pathogenesis of varicelloviruses in primates. J Pathol. 2015;235:298-311.
  7. Wachtman L, Mansfield K. Viral diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardiff S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases Vol 2.  San Diego, CA: Elsevier Inc.; 2012:17-18.


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