October 2018

Signalment:  (JPC# 1782647):  Two-day-old piglet

HISTORY:  This piglet had profuse, watery feces and vomited milk curd.

HISTOPATHOLOGIC DESCRIPTION:  Small intestine with attached mesentery:  Diffusely and circumferentially there is a loss of normal intestinal villar architecture with a dilated lumen and thinned intestinal wall characterized by villi that are severely blunted, shortened, and fused with marked crypt loss, reducing the ratio of villus height to crypt depth to less than 1:1.  The mucosal lining is reduced to a single layer of attenuated basophilic enterocytes, and remaining crypts are lined by either flattened, attenuated epithelium, or hypertrophic epithelial cells that occasionally pile up and contain a moderate amount of foamy basophilic cytoplasm, a large irregularly ovoid nucleus with finely stippled chromatin, one prominent nucleolus and few mitotic figures (regeneration).  Multifocally crypt lumina contain small amounts of eosinophilic cellular and karyorrhectic debris (necrosis) and few macrophages, lymphocytes and plasma cells (crypt abscess). Diffusely, the lamina propria is moderately expanded by lymphocytes and plasma cells.

MORPHOLOGIC DIAGNOSIS:  Small intestine:  Villous necrosis and loss, diffuse, acute, severe with multifocal crypt regeneration and crypt abscesses, breed unspecified, porcine.

ETIOLOGY:  Porcine coronavirus (alphacoronavirus 1)

ETIOLOGIC DIAGNOSIS:  Coronaviral enteritis

CONDITION:  Transmissible gastroenteritis (TGE)







DIFFERENTIAL DIAGNOSIS:  (For diarrhea in piglets)



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