JPC SYSTEMIC PATHOLOGY
ENDOCRINE SYSTEM
February 2019
E-P02 (NP)

Signalment (JPC #1783252):  6-year-old cynomolgus macaque (Macaca fascicularis)

HISTORY:  Incidental finding

HISTOPATHOLOGIC DESCRIPTION:  Adipose tissue, periadrenal:  Expanding the periadrenal adipose tissue are two cross-sections of a 2 x 1.5 mm degenerate pentastome nymph with a 5 um chitinous cuticle that contains pit-like, sclerotized openings to skin glands, a pseudosegmented body wall, prominent body cavity, metamerically arranged (i.e arranged in regular segments) striated muscle, numerous acidophilic glands that surround the intestine and a digestive tract with villi lined by columnar epithelium.  The parasites are surrounded by a 7 um layer of amorphous, eosinophilic material that contains sclerotized openings (previous molt) and a small amount of hemorrhage.

MORPHOLOGIC DIAGNOSIS:  Adipose tissue, periadrenal:  Pentastome nymph, with mild hemorrhage, cynomolgus monkey (Macaca fascicularis), nonhuman primate.

Adrenal gland:  No significant findings.

ETIOLOGIC DIAGNOSIS:  Periadrenal pentastomiasis

CAUSE:  Armillifer armillatus (most likely)

GENERAL DISCUSSION:

PATHOGENESIS:

LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

Other pentastomes that infect nonhuman primates:

COMPARATIVE PATHOLOGY:

Other pentastomes:

REFERENCES:

  1. Bowman DD. Diagnostic parasitology. In: Bowman DD, ed. Georgis’ Parasitology for Veterinarians. St. Louis, MO: Elsevier; 2014:337.
  2. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis: Elsevier; 2016:585.
  3. Dechkajorn S, Nomsiri R, Boonsri K, et al. Visceral pentastomiasis caused by Armillifer armillatus in a captive striped hyena (Hyaena hyaena) in Chiang Mai Night Safari, Thailand. Parasitol Int. 2016;65(1):58-61.
  4. Eberhard ML. Histopathologic diagnosis. In: Bowman DD, ed. Georgis’ Parasitology for Veterinarians. St. Louis, MO: Elsevier; 2014:401-402.
  5. Flynn RJ. Pentastomids. In: Flynn RJ, ed. Parasites of Laboratory Animals. Ames: The Iowa State University Press;1973:493-499.
  6. Gardiner CH, Poynton SL. Morphological characteristics of pentastomes in tissue section. In: Gardiner CH, Poynton SL, ed. An Atlas of Metazoan Parasites in Animal Tissues. Washington, D.C; Armed Forces Institute of Pathology; 1999:59-60.
  7. Strait K, Else JG, Eberhard ML. Parasitic diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. Vol. 2. 2nd ed. San Diego: Academic Press; 2012:271-272.
  8. Tappe D, Meyer M, Oesterlein A. Transmission of Armillifer armillatus ova at snake farm, The Gambia, West Africa. Emerg Infect Dis. 2011;17(2):251-254.


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