JPC SYSTEMIC VETERINARY PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-N09

SIGNALMENT (JPC #2843592):  Female rat

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Haired skin with clitoral gland:  Markedly expanding the clitoral gland is a 1.5 cm, encapsulated, well circumscribed neoplasm composed of polygonal to squamous epithelial cells with a peripheral basaloid reserve layer arranged in broad cords, variably sized acini, islands, and trabeculae surrounding a fine but markedly edematous fibrovascular stroma.  Neoplastic cells have indistinct borders and moderate amounts of eosinophilic fibrillar to microvacuolated cytoplasm often obscured by numerous brightly eosinophilic, intracytoplasmic globules (secretory product).  Nuclei are oval with finely stippled chromatin and a single distinct magenta nucleolus.  Anisocytosis and anisokaryosis are mild.  Mitoses average approximately 5 per HPF.  The neoplastic projections surround central lumina which contains degenerating cells and an eosinophilic flocculent secretory product admixed with neutrophils and macrophages; multifocally basal cells progress toward a central duct lined by hyperkeratotic keratinizing stratified squamous epithelium containing the previously described secretory product composed of degenerating cells admixed with  keratin low numbers of neutrophils, erythrocytes, and small colonies of cocci. The main clitoral gland excretory duct is markedly ectatic, hyperkeratotic, and confluent with the neoplasm and contains similar debris, keratin and secretory product.  Within the adjacent subcutis and dermis, there are multifocal infiltrates of scattered Iymphocytes and plasma cells. 

MORPHOLOGIC DIAGNOSIS:  Clitoral gland:  Adenoma, strain not specified rat, rodent.

SYNONYM(S): Preputial gland adenoma

GENERAL DISCUSSION:

TYPICAL GROSS FINDINGS

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th Ames, IA: John Wiley and Sons, Inc. 2016:164.
  2. Brix AE, Nyska A, Haseman JK, Sells DM, Jokinen MP, Walker NJ. Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program. Toxicol Pathol; 2005(33):477-83.
  3. Rudmann D, Cardiff R, Chouinard L, Goodman D, Küttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K; INHAND Mammary, Zymbal's, Preputial, and Clitoral Gland Organ Working Group. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol. 2012 Aug;40(6 Suppl):7S-39S.
  4. Seely JC, Boorman GA. Mammary gland and specialized sebaceous glands. In: Maronpot RR, Boorman GA, Gaul BW, eds. Pathology of the Mouse. Vienna, IL: Cache River Press; 1999:624-633.
  5. Verin R, Cian F, Stewart J, Binanti D, MacNeill AL, Piviani M, Monti P, Baroni G, Le Calvez S, Scase TJ, Finotello R. Canine clitoral carcinoma: a clinical, cytologic, histopathologic, immunohistochemical, and ultrastructural study. Vet Pathol. 2018 Jul;55(4):501-509.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |