JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-N15 (NP)

Signalment (JPC #3049000):  An 8-year-old female spayed Belgian shepherd

HISTORY:  Tissue from the right-side, fourth and fifth mammary glands

HISTOPATHOLOGIC DESCRIPTION:  Mammary gland:  Expanding the subcutis, infiltrating surrounding adipose and mammary tissue, and extending to a submitted margin, is an unencapsulated multilobulated neoplasm composed of polygonal cells arranged in islands and trabeculae on a fine to moderate fibrovascular stroma.  Neoplastic cells have distinct cells borders with moderate to abundant eosinophilic cytoplasm containing numerous small vacuoles or a single large discrete vacuole (lipid) that frequently peripheralize the nucleus. Nuclei are round to oval with coarsely stippled chromatin and 1 variably distinct nucleolus, or are flattened and hyperchromatic. Anisocytosis and anisokaryosis are moderate. Mitoses average less than 1 per 10 HPF. Islands of neoplastic cells are separated and surrounded by thick bands of fibrous connective tissue.  Multifocally, neoplastic cells are within blood and lymphatic vessels. Scattered throughout the neoplasm are aggregates of lymphocytes, plasma cells, and fewer neutrophils, occasionally admixed with necrotic debris and areas of hemorrhage with few hemosiderin-laden macrophages.

MORPHOLOGIC DIAGNOSIS:  Mammary gland, right fourth and fifth mammae (per contributor):  Lipid-rich carcinoma, Belgian shepherd, canine.

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

REFERENCES:

  1. Foster RA. Female reproductive system and mammae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017:1191-1192.
  2. Goldschmidt MH, Pena L, Rasotto R, Zappulli V. Classification and grading of canine mammary tumors. Vet Pathol. 2011;48(1):117-131.
  3. Goldschmidt MH, Pena L, Zappulli V. Tumors of the Mammary Gland. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th Ames, IA: John Wiley & Sons, Inc.; 2017:751.
  4. Kamstock DA, Fredrickson R, Ehrhart EJ. Lipid-rich carcinoma of the mammary gland in a cat. Vet Pathol. 2005;42:360-362.
  5. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Pathology of Domestic Animals. 6th Vol. 3. St. Louis, MO: Elsevier; 2016:460-463.
  6. Yoshimura H, Kimura-Tsukada N, Ono Y, et al. Characterization of spontaneous mammary tumors in domestic Djungarian hamsters (Phodopus sungorus). Vet Pathol. 2015;52(6):1227-1234.


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