JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-T16

SIGNALMENT (JPC #1803541): Seven-year-old Angus cow

HISTORY: Three of four ill animals in a herd of forty died after an illness of about two weeks. Clinical signs in this cow included bloody diarrhea. Other ill animals were constipated and several had a papular or scaly dermatitis.

HISTOPATHOLOGIC DESCRIPTION: Kidney: Multifocally scattered throughout the cortex and extending into the medulla, are multifocal-coalescing aggregates of macrophages, eosinophils, multinucleated giant cell macrophages (foreign body and Langhans type), lymphocytes and plasma cells admixed with multifocal minimal hemorrhage, fibrin and edema, which expand the interstitium and separate, surround, and replace medullary and cortical tubules and glomeruli. Tubules are mildly to moderately ectatic, contain sloughed tubular epithelium, variable amounts of proteinaceous fluid or necrotic celluar debris.  Multifocally, tubular epithelium is either swollen with vacuolated cytoplasm (degeneration), shrunken with pyknosis and hypereosinophilic cytoplasm (necrosis) or with basophilic cytoplasm and crowded and vesiculate nuclei (regeneration). Multifocally, there is mild parietal epithelial hypertrophy that is occasionally attached to the glomerular tuft (synechia) with occasional ectatic uriniferous spaces containing protein.

MORPHOLOGIC DIAGNOSIS: Kidney: Nephritis, interstitial, granulomatous and eosinophilic, multifocal to coalescing, moderate, with tubular degeneration, necrosis, and regeneration, Angus, bovine.

ETIOLOGIC DIAGNOSIS: Hairy vetch (toxic) nephritis

CAUSE: Hairy Vetch (Vicia villosa Roth) toxicity

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

References:

  1. Breshears MA, Confer AW. The urinary system, In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016:662-674.
  2. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. 6th ed. Vol 2. Philadelphia, PA: Elsevier Saunders;2016:432.
  3. Hargis AM, Myers S. Integumentary System. In: Zachary JF, eds. Pathologic basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Inc; 2016:1066. 
  4. Izuka A, Haritani M, Shiono M, Sato M, Fukuda O. An outbreak of systemic granulomatous disease in cows with high milk yields. J Vet Med Sci 2005;67(7):693-99.
  5. Jones TC, Hunt RD, King NW. Veterinary Pathology. 6th ed. Baltimore, MD: Williams and Wilkins; 1997:723.
  6. Mauldin EA, Peters-Kennedy J. Integumentary System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 1. 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: 1:574.
  7. Saunders GK, et al. Suspected citrus pulp toxicosis in dairy cattle. J Vet Diagn Invest 2000;12:269-271.

 

 


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