JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
August 2018
D-B07

Signalment (JPC #1214032):  Juvenile rhesus monkey (Macaca mulatta)

HISTORY:   This monkey had intractable diarrhea.

HISTOPATHOLOGICAL DESCRIPTION:  Colon: Diffusely, and most severe over Peyer’s patches, there is partial to full thickness mucosal necrosis with abundant hemorrhage, fibrin, eosinophilic cellular and karyorrhectic debris, degenerate neutrophils, and scattered superficial colonies of bacteria.  Occasionally, remaining intestinal crypts are ectatic, lined by attenuated epithelium, and contain sloughed epithelial cells admixed with degenerate neutrophils(crypt abscesses).  Multifocally, blood vessels in the lamina propria and submucosa are variably occluded by finely fibrillary to polymerized/hyalinized eosinophilic fibrin admixed with enmeshed degenerative inflammatory cells(fibrin thrombi).  Diffusely, the submucosa is moderately expanded by increased clear space with ectatic lymphatics (edema) and finely beaded eosinophilic fibrin admixed with moderate numbers of degenerate neutrophils and fewer numbers of lymphocytes and plasma cells, and multifocal mild hemorrhage.  The mucosa associated lymphoid tissue (MALT) contains decreased numbers of lymphocytes and increased numbers of tingible body macrophages admixed with necrotic debris (lymphoid depletion).  

MORPHOLOGIC DIAGNOSIS:  Colon: Colitis, necrohemorrhagic, acute, diffuse, severe, with fibrin thrombi, lymphoid depletion and edema, Rhesus monkey (Macaca mulatta), nonhuman primate.

ETIOLOGIC DIAGNOSIS:  Colonic shigellosis

ETIOLOGY:  Shigella spp.

CONDITION:  Bacillary dysentery

GENERAL DISCUSSION: 

  1. dysenteriae
  2. flexneri
  3. boydii
  4. sonnei

 PATHOGENESIS: 

 TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

Gross and microscopic findings:

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Simmons J, Gibson S. Bacterial and Mycotic Diseases of Nonhuman Primates. In: Abee CR, Mansfield K, Tardif S, et al. Nonhuman primates in biomedical research: Diseases. Vol 2.  San Diego, CA: Academic Press; 2012: 136-138.
  2. Brady AG, Carville AL. Digestive System Diseases of Nonhuman Primates. In: Abee CR, Mansfield K, Tardif S, et al. Nonhuman primates in biomedical research: Diseases. Vol 2.  San Diego, CA: Academic Press; 2012: 599-600.
  3. Brogden KA. Cytopathology of pathogenic prokaryotes.  In: Cheville NF, ed. Ultrastructural pathology: The comparative cellular basis of disease. 2nd ed. Danvers, MA: Wiley-Blackwell; 2009: 474-475.
  4. Greene C. Shigellosis. In: Greene C, ed. Infectious diseases of the dog and cat. 4th ed. St. Louis, MO: Saunders; 2012: 360-361.
  5. Turner JR. The gastrointestinal tract. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran: Pathologic basis of disease. 9th ed. Philadelphia, PA: Saunders; 2015: 787-788.6. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed. Vol 2. Philadephia, PA: Elseveier; 2016:72, 158, 162, 166.


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