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Read-Only Case Details Reviewed: Sep 2008



August 2017



Signalment ( #87-650):  Rhesus monkey

HISTORY:  This monkey was found dead in its cage.

HISTOPATHOLOGIC DESCRIPTION:  SLIDE A:  Lung:  Up to 75% percent of the parenchyma is replaced by multifocal to coalescing granulomas composed of necrotic centers with occasional mineralization surrounded by numerous epithelioid macrophages, multinucleated giant cells (Langhans and foreign body type), and more peripherally by lymphocytes and plasma cells.  Some granulomas are circumscribed by a thin fibrous connective tissue capsule.  Multifocally, remaining alveolar septa are lined by hyperplastic type II pneumocytes. Alveolar spaces contain eosinophilic proteinaceous material (edema) admixed with numerous foamy alveolar macrophages, fewer lymphocytes, and scattered hemorrhage and fibrin.  Multifocally, aggregates of lymphocytes and plasma cells surround blood vessels, which occasionally contain fibrin thrombi.  Diffusely, the pleura is thickened to up to 2 mm by fibrosis, lymphocytes, plasma cells, distended lymphatics (edema), and hemorrhage.  Multifocally, there is mild anthracosilicosis. 

SLIDE B:  Acid-fast stain:  There are rare, intrahistiocytic, 0.5 um wide, acid-fast bacilli.

MORPHOLOGIC DIAGNOSIS:  Lung:  Granulomas, chronic, multifocal to coalescing, severe, with diffuse pleural fibrosis and rare intrahistiocytic acid-fast bacilli, Rhesus monkey (Macaca mulatta), nonhuman primate.

ETIOLOGIC DIAGNOSIS:  Mycobacterial pneumonia

CAUSE:  Mycobacterium tuberculosis

CONDITION:  Tuberculosis

Signalment (#48.863-ML): 11 month-old, male Sannen goat (Capra aegagrus hircus)

HISTORY: This animal was part of a herd that had previously tested positive for bovine tuberculosis.  It presented with fever, dyspnea, and claudication and tested positive for tuberculin cervical skin test.

SLIDE C: Lung: Affecting approximately 40% of this section, there are multifocal to coalescing granulomas that efface the pulmonary parenchyma, compress adjacent alveolar septa, collapsing the alveolar spaces, and elevate the pleural surface.  Granulomas are centered on large areas of lytic necrosis with abundant eosinophilic karryorhectic and cellular debris with aggregates of mineral, surrounded by a layer of viable and degenerate neutrophils, surrounded by epithelioid macrophages with occasional multi-nucleated giant cells (Langhann’s and foreign-body type), further surrounded by lymphocytes and plasma cells with a rim of fibrous connective tissue.  Adjacent alveolar septa are congested and thickened by macrophages, neutrophils, lymphocytes, and plasma cells. Alveoli occasionally contain pale eosinophilic fluid (edema) with increased numbers of alveolar macrophages.  Blood vessels are occasionally surrounded by aggregates of lymphocytes and plasma cells.  There is perivascular edema surrounding larger vessels.  The pleural surface is moderately thickened by edema and increased fibrous connective tissue with scattered macrophages.

MORPHOLOGIC DIAGNOSIS: Lung: Granulomas, chronic, multifocal to coalescing, marked, Sannen goat (Capra aegagrus hircus), caprine.

ETIOLOGIC DIAGNOSIS: Mycobacterial pneumonia

CAUSE: Mycobacterium bovis

CONDITION: Tuberculosis











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