JPC SYSTEMIC PATHOLOGY

INTEGUMENT SYSTEM

November 2016

I-V07 (NP)

 

Signalment (JPC 1856170):  2.5-year-old female grey kangaroo (Macropus fuliginosus)

HISTORY:  Two cutaneous masses, one on the right distal tibia and one on the left forelimb digit, were excised.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  Arising from the epidermis and compressing the subjacent dermis is a focally extensive, exophytic, papillary, epidermal proliferation with multiple closely associated elongated folds with central cores of lamellated keratin and necrotic debris. The stratum spinosum is expanded by keratinocytes that frequently exhibit ballooning degeneration with pale swollen cytoplasm and often contain a single 15 - 20 µm amphophilic to basophilic irregularly shaped intracytoplasmic viral inclusion body (molluscum body) surrounded by a clear halo that peripherally displaces the nucleus.  There is moderate parakeratotic hyperkeratosis and a serocellular crust composed of viable and degenerate neutrophils, fibrin, erythrocytes, and high numbers of expelled molluscum bodies. Diffusely there is marked epidermal and follicular hyperplasia with acanthosis and hypergranulosis.  The subjacent dermis is infiltrated by nodular aggregates of moderate numbers of lymphocytes, plasma cells, macrophages and fewer viable and degenerate neutrophils.

MORPHOLOGIC DIAGNOSIS:  Haired skin: Hyperplasia, epidermal and follicular, papillary, marked, with parakeratotic hyperkeratosis, lymphoplasmacytic and histiocytic dermatitis, and numerous intracytoplasmic viral inclusion bodies (molluscum bodies), grey kangaroo (Macropus fuliginosus), marsupial

ETIOLOGY:  Molluscum contagiosum virus

ETIOLOGIC DIAGNOSIS:  Molluscipoxviral dermatitis

CONDITION:  Molluscum contagiosum

GENERAL DISCUSSION: 

PATHOGENESIS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURE: 

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:

Animal poxviruses in subfamily Chordopoxvirinae5

Orthopoxvirus

·         Cowpox virus

·         Vaccinia virus (buffalopox virus, rabbitpox virus)

·         Horsepox virus

·         Camelpox virus

·         Ectromelia virus (mousepox virus)

·         Monkeypox virus

Unassigned member of the genus:

·         Uasin Gishu disease virus

Parapoxvirus

·         Orf virus (contagious pustular dermatitis virus, contagious ecthyma virus)

·         Pseudocowpox virus (milker's nodule virus)

·         Bovine papular stomatitis virus

·         Parapox virus of red deer

Unassigned members in the genus:

·         Auzduk disease virus (camel contagious ecthyma virus)\

·         chamois contagious ecthyma virus

·         sealpox virus

Avipoxvirus

·         Fowlpox virus

·         Pigeonpox virus

Capripoxvirus

·        Sheeppox virus

·        Goatpox virus

·        Lumpy skin disease virus

Leporipoxvirus

·        Myxoma virus

·        Rabbit fibroma virus (Shope fibroma virus)

Suipoxvirus

·         Swinepox virus

Molluscipoxvirus

·        Molluscum contagiosum virus

Yatapoxvirus

·         Tanapox virus

·         Yaba monkey tumor virus

 

REFERENCES: 

  1. Abee CR, Mansfiled K, Tardif S, Morris T. Nonhuman primates in biomedical research. Volume 2: Diseases. 2nd San Diego, CA:  Elsevier; 2012:7.
  2. Fox R, Thiemann A, Everest D, Steinbach F, Dastjerdi A, Finnegan C. Molluscum contagiosum in two donkeys.Vet Rec. 2012;170:649-651.
  3. Hargis AM, Myers S. The integument. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Mosby Elsevier; 2016:1119.
  4. MacLachlan NJ, Dubovi EJ. Fenner’s Veterinary Virology, 4th ed. London, UK: Elsevier; 2011: 161.
  5. Maudlin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th Philadelphia, PA: Elsevier Saunders; 2016: 616, 621.
  6. Scott DW, Miller WH. Equine Dermatology. 2nd ed. St Louis: Elsevier Saunders; 2011: 253-255.
  7. Vermi W, et al. Spontaneous regression of highly immunogenic molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J Invest Dermatol. 2011:131(2); 426-434.


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