October 2017



Signalment (JPC # 4066069):  Tissue from an ox.

HISTORY:  Unknown

HISTOPATHOLOGIC DESCRIPTION:  Lung: Diffusely affecting 100% of the section bronchi and bronchioles, are expanded by an exudate composed of viable and degenerate neutrophils, eosinophilic cellular and karyorrhectic debris, alveolar macrophages, sloughed epithelial cells, fibrin, hemorrhage, and edema. Bronchiolar and bronchial epithelium are characterized by one or more of the following changes: epithelial necrosis, attenuation, hyperplasia (up to 8 cell layers thick), and viral syncytial cell formation (with up to 8 nuclei) with cells budding off the epithelium into the lumen. Multifocally, there are 3-6 um, round to oval, brightly eosinophilic intracytoplasmic inclusion bodies in respiratory epithelium and syncytial cells. Alveolar lumina are variably expanded by moderate to abundant amounts of fibrin, edema, hemorrhage, small amounts of necrotic debris, neutrophils, and  macrophages, which are admixed with viral syncytial cells.  Alveolar septa are moderately expanded by eosinophilic beaded fibrillar material (fibrin), macrophages, fewer neutrophils, syncytial cells, hemorrhage and edema, or replaced with eosinophilic cellular and karyorrhectic debris (septal necrosis).  There is type II pneumocyte hyperplasia. Interlobular septa and visceral pleura are moderately expanded by hemorrhage, fibrin, and edema, and in the perivascular connective tissue there are also markedly ectatic lymphatic vessels.

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, bronchointerstitial, necrotizing, suppurative and histiocytic, subacute, multifocal, moderate, with bronchiolar viral syncytial cells and epithelial eosinophilic intracytoplasmic viral inclusions, breed unspecified, bovine.

ETIOLOGY DIAGNOSIS:  Paramyxoviral pneumonia

CAUSE:  Bovine Respiratory Syncytial Virus (BRSV)






(Acute lesions): 1-8 days post infection

(Subacute lesions): > 8 days post infection






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