JPC SYSTEMIC PATHOLOGY

INTEGUMENTRY SYSTEM

October 2013

I-N07

 

Signalment (JPC #2147437):  Dog

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  Expanding the deep dermis and subcutis, elevating the overlying dermis and epidermis, and extending to one cut border is a multilobulated, unencapsulated, well circumscribed, densely cellular neoplasm composed of polygonal cells arranged in haphazard ductules and islands separated by variably thick bands of fibrous connective tissue.  Ductules often have slit-like lumens lined by double layers of epithelial cells.  The luminal layer is composed of cuboidal cells that have variably distinct cell borders, scant to moderate amounts of eosinophilic granular cytoplasm, oval nuclei with finely stippled chromatin and generally one distinct nucleolus.  Cells on the abluminal layers are more flattened and often oriented parallel to the basal lamina.  There is mild anisocytosis, anisokaryosis, and mitotic figures average 1 per 40x HPF.  Tubules are often distended up to 1.5 mm diameter with brown to amphophilic granular secretory product with clear, acicular cholesterol clefts.  Multifocally, there is squamous differentiation of tubular epithelium with intraluminal lamellations of keratin which primarily exhibit gradual keratinization characterized by the presence of keratohyalin granules.  Scattered within the fibrous connective tissue and within tubules are moderate numbers of secretory product-laden macrophages.   

MORPHOLOGIC DIAGNOSIS:  Haired skin and subcutis:  Apocrine ductular adenoma, breed unspecified, canine. 

CONDITION:  Apocrine ductular adenoma; epitrichial ductular adenoma

SYNONYMS:  Basaloid apocrine adenoma

GENERAL DISCUSSION:

 PATHOGENESIS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:

References: 

  1. Cihocki LM, Divers TJ, Johnson AL, Warren AL, Schramme M, Rassnick KM, Scott DW. A case of multiple epitrichial sweat gland ductal carcinomas in a horse. Vet Dermatol. 2007;18(2):134-137.
  2. Goldschmidt MH, Dunstan RW, Stannard AA, von Tscharner C, Walder EJ, Yager JA. Histological Classification of Epithelial and Melanocytic Tumors of the Skin of Domestic Animals, 2nd Series, Vol. III. Washington, DC: Armed Forces Institute of Pathology; 1998: 28-32, 69-71.
  3. Goldschmidt MH, Hendrick MJ. Tumors of the skin and soft tissues. In: Meuten DJ, ed. Tumors in Domestic Animals, 4th ed. Ames, IA: Iowa State Press; 2002: 70-74.
  4. Goldschmidt MH, Shofer FS. Skin Tumors of the Dog and Cat. Oxford, England: Pergamon Press; 1992: 85-89.
  5. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat, 2nd ed. Ames, IA: Blackwell Science; 2005: 625-634,672-674.
  6. Pieper JB, Stern AW, LeClerc SM, Campbell KL. Coordinate expression of cytokeratins 7 and 14, vimentin, and Bcl-2 in canine cutaneous epithelial tumors and cysts.  J Vet Diagn Invest. 2015; 27(4): 497-503.
  7. Scott DW, Miller WH. Equine Dermatology. St. Louis, MO: WB Saunders; 2003: 717.


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