JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-T06

Signalment (JPC # 1947999):  Hampshire ewe

HISTORY:  This tissue is from a 4-year-old Hampshire ewe that became ill 36 hours after initial access to a new field. Clinical signs included salivation, mydriasis, tremors, ataxia, and paresis. 

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Multifocally and predominantly within the cortex, tubules are ectatic, expanded up to 4 times normal, and lined by epithelium that is either attenuated, degenerative (characterized by pale, vacuolated cytoplasm), necrotic (characterized by fragmented, hypereosinophilic cytoplasm and pyknosis), or regenerative (characterized by increased mitotic activity and large pale basophilic nuclei with a high nuclear to cytoplasmic ratio and piling up of epithelium).  Tubules often contain intraluminal yellow, translucent, variably shaped, angular, prismatic, anisotropic crystals; rare small amounts of eosinophilic amorphous material (protein); rare sloughed epithelial cells; or, intensely basophilic acellular, fragmented material (mineral).  The interstitium and perivascular connective tissue are mildly expanded by eosinophilic amorphous fluid (edema), eosinophilic beaded to fibrillar material (fibrin) and mild hemorrhage admixed with low numbers of neutrophils, lymphocytes and plasma cells. 

MORPHOLOGIC DIAGNOSIS:  Kidney, tubules:  Degeneration and necrosis, diffuse, moderate with marked tubular ectasia and numerous intratubular oxalate crystals, breed unspecified, ovine.  

ETIOLOGIC DIAGNOSIS:  Oxalate nephrosis 

GENERAL DISCUSSION: 

Halogeton glomeratus (halogeton); Sarcobatus vermiculatus (greasewood); Rheum rhaponticum  (rhubarb); Oxalis spp. (sorrel, soursop); Rumex spp. (sorrel, dock); Amaranthus sp. (pigweed)
Beta spp. (beet, marigold); Brassica spp. (cauliflower, broccoli, kale, rape); Chenopodium album (lamb’s quarters); Portulaca oleracea (purslane); Salsola kali (Russian thistle); Setaria spp. (tropical grass)

 PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY

REFERENCES:

  1. Cianciolo RE, Mohr FC. The urinary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals.Vol 2. 6th ed. Philadelphia, PA: Saunders; 2016:425, 456-457.
  2. Botha CJ, Truter M, Bredell T, Lange L, Mulders MG. Putative aspergillus niger-induced oxalate nephrosis in sheep. J South African Vet Assoc. 2009;80(1):50-53.
  3. Brown CA, Jeong K, Poppenga RH, et al. Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. J Vet Diagn Invest. 2007;19:525-531.
  4. Gulbahar MY, Kaya A, Golen I. Renal oxalosis in a calf. Turk J Vet Anim Sci. 2002;26:1197-1200.
  5. Mitchell EP, Church ME, Nemser SM, et al. Pathology and epidemiology of oxalate nephrosis in cheetahs. Veterinary Pathology. 2017;54(6):977-985.
  6. Naude TW, Naidoo V. Oxalates-containing plants. In: Gupta RC, ed. Veterinary Toxicology. Oxford, UK: Elsevier; 2007:880-890.
  7. Panciera RJ, Martin T, Burrows GE, Taylor DS, Rice LE. Acute oxalate poisoning attributable to ingestion of curly dock (Rumex crispus) in sheep. J Am Vet Med Assoc. 1990;196:1981-1984.
  8. Rhyan JC, Sartin EA, Powers RD, Wolfe DF, Dowling PM, Spano JS. Severe renal oxalosis in five young Beefmaster calves. J Am Vet Med Assoc. 1992;201:1907-1910.
  9. Speight KN, Boardman W, Breed WG, et al. Pathological features of oxalate nephrosis in a population of koalas (Phascolarctos cinereus) in South Australia. Veterinary Pathology. 2012;50(2):299-307.

 


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