JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-M07

Signalment (JPC # 2551104):  A nonpregnant female rabbit.

HISTORY:  This rabbit, housed singly under standard laboratory conditions, showed extensive vaginal bleeding and died.

HISTOPATHOLOGIC DESCRIPTION:  Uterus:  Focally expanding the endometrium is a markedly dilated (up to 5 mm diameter) vein lined by attenuated or hyperplastic endothelial cells (venous aneurysm) that is occluded by concentric lamellations of erythrocytes and fibrin with scattered enmeshed heterophils and lymphocytes, and few reactive fibroblasts (organizing thrombus) which is multifocally adherent to the disrupted endothelium.  The adjacent endometrium contains golden brown pigment-laden macrophages (hemosiderosis).  The remainder of the endometrium is mildly expanded by many papillary projections of hyperplastic endometrium with few ectatic glands that are lined by cuboidal to low columnar, often ciliated epithelium (endometrial hyperplasia).  Diffusely the lamina propria is expanded by increased clear space and ectatic lymphatics (edema).

MORPHOLOGIC DIAGNOSIS: 

  1. Uterus, endometrium:  Aneurysm, venous, multiple, with organizing thrombosis, breed unspecified rabbit, lagomorph.
  2. Uterus: Endometrial hyperplasia, diffuse, mild. 

CONDITION:  Endometrial venous aneurysm

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

References:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016:310-311.
  2. Bray MV, Weir EC, Brownstein DG, Delano ML. Endometrial venous aneurysms in three New Zealand white rabbits. Lab An Sci 1992;42:360-362.
  3. Mitchell RN. Blood vessels. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Saunders Elsevier; 2015:501-505.


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