JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-M23 (NP)

Signalment (JPC # 870468-10):  Rhesus monkey

HISTORY:  Incidental histopathologic finding in a Rhesus monkey

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Multifocally lining the collecting ducts of the inner medulla, there are several multinucleate cells, up to 4 per HPF, with up to 20 nuclei which are morphologically similar to nuclei within adjacent normal epithelial cells.  These cells have a moderate amount of vacuolated eosinophilic cytoplasm, and frequently bulge into the tubular lumen.  Papillary ducts are lined by stratified cuboidal epithelium and multifocally contain fewer previously-described multinucleated epithelial cells.  

MORPHOLOGIC DIAGNOSIS:  Kidney, medulla, collecting tubule and papillary duct epithelium: Multinucleated epithelial cells, multifocal, few, rhesus macaque (Macaca mulatta), nonhuman primate.

CAUSE:  Incidental finding

GENERAL DISCUSSION: 

 PATHOGENESIS:

Unknown

 TYPICAL CLINICAL FINDINGS:

None

TYPICAL GROSS FINDINGS:

None

TYPICAL LIGHT MICROSCOPIC FINDINGS:

lower portion of the medulla (from the mid-medulla to the tip of the renal papilla)

ADDITIONAL DIAGNOSTIC TESTS:

None

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Harman MB, Hogan JM. Multinucleated epithelial cells in the tubules of the human kidney. Arch Pathol.1949;47:29.
  2. O’Donnell M, Fleming S. The renal pathology of mushroom poisoning. Histopathology. 1997;30:280-282.
  3. Seaman WJ. Multinucleated epithelial cells of renal collecting tubules in macaques. Vet Pathol. 1986;23:87-88.

 


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