JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
November 2018
D-V10

SIGNALMENT (JPC# 3071894):  Muscovy duck 

HISTORY:  This duck was one of 2 birds to die from a total of 75 ducks, and no clinical history was given.

HISTOPATHOLOGIC DESCRIPTION:  Liver: Multifocally and randomly affecting approximately 50% of the liver, there are variably sized areas of lytic necrosis characterized by a loss of normal hepatic architecture, discontinuity of hepatic cords, necrotic hepatocytes with shrunken, hypereosinophilic cytoplasm and a pyknotic nucleus, and aggregates of eosinophilic cellular and karyorrhectic debris. Adjacent hepatocytes are frequently individualized, and are swollen with either finely vacuolated cytoplasm (glycogen-type degeneration) or few large, discrete clear vacuoles which displace the nucleus (lipid degeneration). Adjacent to areas of degeneration and necrosis, numerous hepatocytes and rare biliary epithelial cells contain single round, 3-8 um diameter eosinophilic intranuclear viral inclusion bodies surrounded by a clear halo that often marginates the chromatin. Multifocally, there are increased biliary duct profiles (biliary ductal reaction).

MORPHOLOGIC DIAGNOSIS:  Liver: Hepatocellular necrosis and degeneration, acute, multifocal - random, moderate, with biliary ductal reaction and numerous hepatocellular and bile duct epithelial eosinophilic intranuclear viral inclusion bodies, Muscovy duck (Cairina moschata), avian.

ETIOLOGIC DIAGNOSIS:  Alphaherpesviral hepatitis 

CAUSE:  Anatid herpesvirus 1 (Duck enteritis or duck plague virus)

CONDITION:  Duck viral enteritis

CONDITION SYNONYM:  Duck plague

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

Hemorrhagic and necrotic lesions in anseriforms:

Intranuclear inclusions in hepatocytes of ducks:

COMPARATIVE PATHOLOGY: 

Other significant alphaherpesviruses:

REFERENCES:

  1. Bennett BT, Abee CR, Henrickson R. Nonhuman Primates in Biomedical Research: Diseases. San Diego, CA: Academic Press, Inc.; 1998:5-16.
  2. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:537-538.
  3. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier; 2016:625-627.
  4. Ojkic D, Brash ML, Jackwood MW, Shivaprasad HL. Viral diseases.  In: Boulianne M, ed.  AvianDisease Manual. 7th ed. Jacksonville, FL: American Association of Avian Pathologists, Inc; 2013:42-43.
  5. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:432-433.


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