JPC SYSTEMIC PATHOLOGY
CARDIOVASCULAR SYSTEM
May 2019
C-V02 (NP)

SIGNALMENT (JPC #2133912):  A pig

History:  None

HISTOPATHOLOGIC description:  Heart, ventricle:  Multifocally disrupting the epicardium, myocardium, and endocardium and surrounding, separating, isolating, and replacing cardiac myocytes are high numbers of lymphocytes, plasma cells, and macrophages, moderate amounts of clear space (edema), eosinophilic fibrillar material (fibrin), and basophilic granular material (mineral).  Within affected areas, cardiac myocytes are swollen with vacuolated sarcoplasm (degeneration) or shrunken with hypereosinophilic sarcoplasm, loss of cross striations, and pyknosis (necrosis). 

Morphologic diagnosis:  Heart:  Pancarditis, lymphoplasmacytic and histiocytic, multifocal, severe, with myocardial necrosis, breed unspecified, porcine.

cause:  Encephalomyocarditis virus (EMCV)

Etiologic diagnosis:  Picornaviral myocarditis

General discussion:

Pathogenesis:

typical Clinical findings:

typical Gross findings:

typical light MICROSCOPIC findings:

ULTRASTRUCTURE:

ADDITIONAL DIAGNOSTIC TESTS:

Differential diagnosis:

Myocarditis in pigs:

Edema:

Reproductive Failure:

Comparative pathology:

References:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016: 35.
  2. Duncan M.   In: Terio KA, McAllose D, St. Leger J, eds.  Pathology of Wildlife and Zoo Animals.  San Diego, CA: Elsevier; 2018:446-447..
  3. Jones MEB, Gasper DJ, Mitchell E. Bovidae, antilocapridae, giraffidae, tragulidae, hippopotamidae. In: Terio KA, McAllose D, St. Leger J, eds.  Pathology of Wildlife and Zoo Animals.  San Diego, CA: Elsevier; 2018:119, 129.
  4. Landolfi JA, Terrell SP.   In: Terio KA, McAllose D, St. Leger J, eds.  Pathology of Wildlife and Zoo Animals.  San Diego, CA: Elsevier; 2018:421, 424n.
  5. Lowenstine LJ, McManamon R, Terio KA.   In: Terio KA, McAllose D, St. Leger J, eds.  Pathology of Wildlife and Zoo Animals.  San Diego, CA: Elsevier; 2018:389.
  6. McAloose D, Stalis IH. In: Terio KA, McAllose D, St. Leger J, eds.  Pathology of Wildlife and Zoo Animals.  San Diego, CA: Elsevier; 2018:334.
  7. Miller LM, Gal A. Cardiovascular system and lymphatic vessels. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Mosby Elsevier; 2016: 606.
  8. Qin S, Underwood D, Driver L, Kistler C, Diallo I, Kirkland PD. Evaluation of a duplex reverse-transcription real-time PCR assay for the detection of encephalomyocarditis virus.  J Vet Diagn Invest. 2018;30(4):554-559.
  9. Robinson WF, Robinson NA. Cardiovascular system. In: Grant Maxie M, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier; 2016:43.
  10. Salogni C, Lazzaro M, Giacomini E, et. al. Infectious agents identified in aborted swine fetuses in a high-density breeding area: a three-year study.  J Vet Diagn Invest.  2016;28(5):550-554.
  11. Wachtman L, Mansfield K. Viral diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, Morris T, eds.  Nonhuman Primates in Biomedical Research.  London, UK: Academic Press; 2012: 73-74.


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