JPC SYSTEMIC PATHOLOGY
ENDOCRINE SYSTEM
January 2019
E-M02 (NP)

SIGNALMENT (JPC #1669664):  3-year-old male German shepherd military working dog

HISTORY:  Incidental finding in a dog that died during anesthesia for treatment of an infected tooth.

HISTOPATHOLOGIC DESCRIPTION (Slide A):  Pituitary gland: Focally separating the pars distalis and pars intermedia and compressing and displacing the pars nervosa is an irregularly round, 4 mm diameter cyst lined by pseudostratified cuboidal to columnar epithelium that is multifocally ciliated. The cyst is filled with amorphous amphophilic homogenous material (mucinous protein). 

MORPHOLOGIC DIAGNOSIS:  Pituitary gland:  Cyst, focal, German shepherd dog, canine.

CONDITION:  Cystic remnant of the craniopharyngeal duct (Rathke's pouch)

SIGNALMENT (JPC #4104652): Maned wolf from National Zoo

HISTORY: None

HISTOPATHOLOGIC DESCRIPTION (Slide B):  Pituitary gland: Multifocally expanding the pars distalis are variably sized pseudocysts ranging from 30um to 1.5mm with no distinct epithelial lining, often surrounded by acidophils and chromophobes, and containing variable amounts of eosinophilic homogenous material (secretory product).

MORPHOLOGIC DIAGNOSIS: Pituitary gland, pars distalis: Pseudocysts, multiple, maned wolf, Chrysocyon brachyurus.   

GENERAL DISCUSSION:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Bakthavatchalu V, Muthupalani S, Marini RP, Fox JG. Endocrinopathy in aging ferrets. Vet Pathol. 2016; 53(2):349-365.
  2. Banks WJ. Applied Veterinary Histology. 3rd ed. St. Louis, MO: Mosby, Inc.; 1993:408-12.
  3. Leitenbacher J, Herbach N. Age-related qualitative histological and quantitative stereological changes in equine pituitary. J Comp Path. 2016; 154(2-3):215-224.
  4. Miller MA. Endocrine system. In: Zachary JF, McGavin MD, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017:717.
  5. Miller MA, Bruyette DS, Scott-Moncrieff JC, Owen TJ, et al. Histopathological findings in canine pituitary glands. Vet Pathol. 2018;55(6):871-879.
  6. Polledo L, Grinwis GCM, Graham P, Dunning M, Baiker K. Pathological findings in the pituitary glands of dogs and cats. Vet Pathol. 2018; 55(6):880-888.
  7. Quintanar-Stephano A, Munoz Fernandez L, Quintanar JL, Kovacs K. Cysts in the rat adenohypophysis: Incidence and histology. Endocr Pathol. 2001; 12(1):63-71.
  8. Rosol TJ, Gröne A. Endocrine glands.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:279-281.


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Click on image for diagnostic series.



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