JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
April 2018
H-N02

Signalment:  2-year-old male castrated domestic longhair cat

HISTORY:  This cat was feline leukemia virus positive.

HISTOPATHOLOGIC DESCRIPTION:  Lymph node:  Diffusely effacing the cortex and medulla is an infiltrative, densely cellular neoplasm composed of diffuse sheets of large lymphocytes on a pre-existing fibrovascular stroma.  Neoplastic cells have distinct borders and scant eosinophilic granular cytoplasm.  Nuclei are large and irregularly round with coarsely stippled chromatin, and 1-2 prominent nucleoli.  Mitoses average 6 per individual high power field.  Multifocally, neoplastic cells are within vessels and there is scattered single cell necrosis.  Subcapsular and medullary sinuses contain moderate hemorrhage, small amounts of fibrin, increased numbers of histiocytes (sinus histiocytosis) that multifocally contain phagocytized erythrocytes and hemosiderin. The capsule and perinodal adipose tissues are mildly expanded by variable amounts of hemorrhage, lymphocytes and macrophages, rare neutrophils, and mild edema.

MORPHOLOGIC DIAGNOSIS:  Lymph node:  Lymphoma, diffuse, large, intermediate grade domestic longhair, feline.

CAUSE:  Feline leukemia virus (FeLV)

ETIOLOGIC DIAGNOSIS:  Feline retroviral lymphoma

GENERAL DISCUSSION:

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:  (Viral-induced lymphomas)

REFERENCES: 

1.  Buch JS, Clark GH, Cahill R et al. Analytical validation of a reference laboratory ELISA for the detection of feline leukemia virus p27 antigen.  J Vet Diag Invest. 2017;29(5): 654-659.

2. Boes KM, Durham AC. Bone marrow, blood cells, and the lymphoid/ lymphatic system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017: 760.
3. Grimes CN, Fry MM.  Nonregenerative anemia: mechanisms of decreased or ineffective erythropoiesis.  Vet Pathol. 2015; 52(2): 298-311. 
4. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier Limited; 2016: 627-628.
5. Lamberski N. Felidae. In: Miller RE, Fowler ME, eds.  Fowler’s Zoo and Wildlife Animal Medicine. Vol. 8. St. Louis, MO: Elsevier Saunders; 2015: 143.
6. Ojkic D, Brash ML, Jackwood MW et al. Viral diseases. In: Boulianne M, ed. Avian disease manual. 7th ed. Jacksonville, FL: OmniPress; 2013: 30-38.
7. Percy DH, Barthold SW.  Pathologyof Laboratory Rodents and Rabbits. 4th ed. Ames, IA: John Wiley & Sons, Inc; 2016:41-41, 176.
8. Roccabianca P, Avallone G, Rodriguez A et al. Cutaneous lymphoma at injection sites: Pathological, immunophenotypical, and molecular characterization in 17 cats. Vet Pathol. 2016 53(4): 823-832.
9. Santagostino AF, Mortellaro CM, Boracchi P et al. Feline upper respiratory tract lymphoma: site, cyto-histology, phenotype, FeLV expression, and prognosis. Vet Pathol. 2015 52(2): 250-259.
10.  Valli VEO, Kiupel M, Bienzle D, Wood RD. Hematopoietic system. In:  Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier Limited; 2016:145, 217-218, 235-236.
11.  Wachtman L, Mansfield K. Viral diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. 2nd ed. London, UK: Academic Press; 2012:20-24.
12.  Zachary JF. Microbial mechanisms of infection. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:220-221.


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