JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES SYSTEM
April 2018
S-M09

Signalment (JPC Accession # 1372926):  German shepherd dog

HISTORY:  Tissue from a German shepherd military working dog.

HISTOPATHOLOGIC DESCRIPTION:  Eye, cornea:  Focally, the superficial third of the corneal stroma is expanded up to 300 µm by moderate numbers of plasma cells, lymphocytes and macrophages, multiple variably-sized vessels lined by hypertrophic endothelial cells (vascularization) and reactive fibroblasts (granulation tissue) and increased clear space (edema).  Few aggregates of macrophages within the stroma contain brown to black, granular to globular pigment (melanin/melanosis).  There are multifocal areas of corneal epithelial erosion with sloughing of epithelium, as well as areas of mild hyperplasia characterized by thickening up to 50 µm wide by hyperplastic epithelial cells, up to 10 layers thick, with few aggregates of interepithelial neutrophils and macrophages (abscesses).  Multifocally, epithelial cells are swollen with pale eosinophilic cytoplasm and occasional intracytoplasmic vacuoles (hydropic degeneration).  The epithelium is heavily pigmented with high numbers of melanocytes in the epithelium.

MORPHOLOGIC DIAGNOSIS:  Eye, cornea:  Keratitis, lymphoplasmacytic and histiocytic, chronic, multifocal, moderate, with epithelial abscesses, stromal and epithelial pigment, vascularization and focal erosion (pannus), German shepherd dog, canine.

CONDITION:  Pannus keratitis

SYNONYMS:  Chronic superficial keratitis (CSK); German shepherd pannus; Uberreiter's syndrome; superficial stromal keratitis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

For keratitis:

COMPARATIVE PATHOLOGY:

For keratitis:

References:

  1. Andrew SE. Immune-mediated canine and feline keratitis. Vet Clin North Am Small Anim Pract. 2008; 38(2):269-290.
  2. Dubielzig RR, Ketring KL, McLellan GJ, Albert DM. The principles and practice of ocular pathology. In: Dubielzig RR, Ketring KL, McLellan GJ, Albert DM, eds. Veterinary Ocular Pathology: a comparative review. Philadelphia, PA: Saunders Elsevier; 2010:2.
  3. Dubielzig RR, Ketring KL, McLellan GJ, Albert DM. Diseases of the cornea and sclera. In: Dubielzig RR, Ketring KL, McLellan GJ, Albert DM, eds. Veterinary Ocular Pathology: a comparative review. Philadelphia, PA: Saunders Elsevier; 2010:212-215.
  4. Labelle P. The eye. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO:  Mosby Elsevier; 2017:1314.
  5. Wilcock BP. Special senses. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Saunders Elsevier; 2016:438.
  6. Williams DL. Histological and immunohistochemical evaluation of canine chronic superficial keratitis. Res Vet Sci. 1999;67(2):191-195.
  7. Williams DL. Major histocompatibility class II expression in the normal canine cornea and in canine chronic superficial keratitis. Vet Ophthalmol. 2005;8(6):395-400.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |