JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-M12

SIGNALMENT (JPC Accession #2694985):  Dog, age and breed unspecified

HISTORY:  Unknown

HISTOPATHOLOGIC DESCRIPTION:  Salivary gland, submandibular:  Affecting 50% of the normal section is a well-demarcated area of coagulative necrosis characterized by retention of tissue architecture with a loss of differential staining (infarct), admixed with multifocal areas of moderate hemorrhage, fibrin, edema, basophilic granular mineral, moderate numbers of neutrophils, and eosinophilic and karyorrhectic debris (lytic necrosis) which multifocally extends into the interlobular interstitium and adjacent capsule. The capsule is also multifocally, mildly thickened by granulation tissue characterized by increased numbers of reactive fibroblasts, fibrous connective tissue, edema, and small-caliber blood vessels. Ducts at the margin of the area of infarction are multifocally separated by fibrosis and are lined by degenerate epithelial cells with swollen, pale, vacuolated cytoplasm (degeneration) that occasionally pile up and fill the duct lumen (hyperplasia), or by multiple layers of flattened epithelium (squamous metaplasia) with lumens filled by a small amount of edema, secretory product and degenerate neutrophils. 

MORPHOLOGIC DIAGNOSIS:  Salivary gland, submandibular:  Coagulative and lytic necrosis, acute, focally extensive, marked with ductular degeneration, hyperplasia and squamous metaplasia (infarct) breed unspecified, canine.

CONDITION:  Salivary gland infarction or canine necrotizing sialometaplasia

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

Grossly enlarged and hemorrhagic salivary gland:

COMPARATIVE PATHOLOGY:

References:

  1. Boydell P, Pike R, Crossley D, Whitbread T. Sialoadenitis in dogs. J Am Vet Med Assoc. 2000;216(6):872-874.
  2. Brooks D, Hottinger H, Dunstan R. Canine necrotizing sialometaplasia: a case report and review of the literature. J Am Anim Hosp Assoc. 1995;31:21-25.
  3. Brown PJ, Bradshaw JM, Sozmen M, Campbell RH. Feline necrotizing sialometaplasia: a report of two cases. J Feline Med Surg. 2004;6(4):279.
  4. Kelly D, Lucke V, Denny H, Lane J. Histology of salivary gland infarction in the dog. Vet Pathol. 1979;16:438-443.
  5. Kim HY, Woo GH, Bae YC, Park YH, Joo YS. Necrotizing sialometaplasia of the parotid gland in a dog. J Vet Diagn Invest. 2010;22(6):975-977.
  6. Saunders GK, Monroe WE. Systemic granulomatous disease and sialometaplasia in a dog with Bartonella Vet Pathol. 2006;43:391-392.
  7. Spangler W, Culbertson M. Salivary gland disease in dogs and cats: 245 cases (1985-1988). J Am Vet Med Assoc. 1991;198(3):465-469.
  8. Uzal FA, Platter BL, Hostetter JM. Alimentary System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed. St. Louis, MO: Elsevier; 2016: 30.


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