JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

October 2017

P-V24

 

Signalment (JPC #2156896): Tissue from a sheep

HISTORY: None

HISTOPATHOLOGIC DESCRIPTION: Lung: Multifocally centering around bronchioles are consolidated nodules (pocks) up to 2mm in diameter composed of alveoli lined by hyperplastic type II pneumocytes and alveolar lumina filled with eosinophilc fluid and hemorrhage, degenerate neutrophils and necrotic debris, lymphocytes and plasma cells, and moderate numbers of macrophages with vesiculate nuclei and abundant amphophilic foamy cytoplasm containing one or more round to oval, 2‑8um diameter, pale eosinophilic intracytoplasmic viral inclusion bodies (sheeppox cells). The bronchioles in the center of the nodules are lined by hyperplastic epithelium that is piled up to five layers deep with transmigrating degenerate neutrophils, and bronchiolar epithelial cells occasionally contain 2-4um diameter eosinophilic intracytoplasmic viral inclusion bodies.  Multifocally bronchioles contain a small amount of fibrinous exudate.  The majority of the remaining alveolar septa are mildly expanded by lymphocytes, macrophages, and neutrophils.  There is mild perivascular edema and the vascular endothelium is hyperplastic. 

MORPHOLOGIC DIAGNOSIS: Lung: Pneumonia, bronchointerstitial, proliferative, subacute, multifocal, moderate, with nodular type II pneumocyte hyperplasia, intrahistiocytic eosinophilic intracytoplasmic viral inclusion bodies (sheeppox cells), and intraepithelial eosinophilic intracytoplasmic viral inclusion bodies, breed unspecified, ovine.

ETIOLOGIC DIAGNOSIS: Capripoxviral pneumonia

CAUSE: Sheeppox virus (Capripoxvirus, ovine strain)

GENERAL:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRCTURAL FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

 REFERENCES:

  1. Beard PM. Lumpy skin disease: a direct threat to Europe. The Veterinary Record. 2016;178(22):557-558.
  2. Beyut E. Sheep pox virus induces proliferation of type II pneumocytes in the lungs. J Comp Pathol. 2010;143(2-3):132-141.
  3. Bhanuprakash V, Indrani BK, Hosamani M, Singh RK. The current status of sheep pox disease. Comp Immun Microbiol Infect Dis. 2006;29:27-60.
  4. Bracht AJ, Armien AG, Carillo C, et al. Isolation and characterization of a cervidpoxvirus from a goitered gazelle (Gazella subgutturosa) from a zoologic park in Minnesota. Journal of Zoo and Wildlife Medicine. 2013;44(3):589-595.
  5. Caswell JL, et al. The respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals, Vol 2, 6th ed. St. Louis, MO: Elsevier; 2016: 483, 557.
  6. Cheville NF. Cytopathology of viral diseases. In: Ultrastructural Pathology. 2nd ed. Ames, IA: Wiley-Blackwell; 2009:324.
  7. Das A, Deng MY, Babiuk S, McIntosh MT. Modification of two capripoxvirus quantitative real-time PCR assays to improve diagnostic sensitivity and include beta-actin as an internal positive control. 2017;29(3):351-356.
  8. Gulbahar MY, Davis WC, Yuksel H, Cabalar M. Immunohistochemical evaluation of inflammatory infiltrate in skin and lungs of lambs naturally infected with sheeppox virus. Vet Pathol. 2006;43:67-75.
  9. Hargis AM, Myers S. The integument. In: McGavin MD, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO:Elsevier; 2016:1123-1124.
  10. Kitching, RP. Sheepox and goatpox. In: Coetzer JAW, Tustin RC, eds. Infectious Diseases of Livestock. 2nd ed. New York City, NY: Oxford; 2004:1277-1281.
  11. MacLachlan NJ, Dubovi EJ, eds. Fenner’s Veterinary Virology. 5th ed. Oxford, UK: Elsevier Academic Press; 2017:164-167.
  12. Mauldin EA, Peters-Kennedy J. Skin and appendages. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. 6th ed. Philadelphia, PA: Elsevier; 2016:622-624.
  13. Zachary JF. Mechanisms of microbial infection. In: McGavin MD, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016:228-229.


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