October 2017



Signalment (JPC #2295198): 9-month-old, mixed breed goa

HISTORY: This goat was found dead 8 days after being inoculated subcutaneously with 1.0 mL of blood product made from a goat with profound respiratory signs. The cranioventral lungs were consolidated and hyperemic. There was accumulation of fibrin on the overlying pleura.

HISTOPATHOLOGIC DESCRIPTION: Lung: Diffusely, alveolar septa are expanded up to three times normal by histiocytes and lymphocytes, there is necrosis and loss of type I pneumocytes and alveoli are lined by type II pneumocytes (hyperplasia). Multifocally replacing both alveolar pneumocytes and bronchiolar epithelium, there are numerous viral syncytia containing up to 30 nuclei. Multifocally, alveolar and bronchiolar epithelial syncytia, type II pneumocytes and bronchiolar epithelial cells contain intranuclear and intracytoplasmic, eosinophilic, oval viral inclusions up to 5 microns in diameter. Bronchial and bronchiolar epithelial cells have one or more of the following changes: attenuation, necrosis, and hyperplasia, which is often irregular and tortuous. Multifocally, the perivascular and peribronchiolar interstitium, interlobular septa, and pleura are expanded by edema, ectatic lymphatics, few neutrophils, lymphocytes, and rare plasma cells. Alveolar spaces, and occasionally bronchiolar lumina, are filled with an exudate composed of viable and degenerate neutrophils, necrotic cellular debris, and fibrin with fewer macrophages, occasional lymphocytes, hemorrhage, and edema.

MORPHOLOGIC DIAGNOSIS: Lung: Pneumonia, bronchointerstitial, lymphohistiocytic, diffuse, severe, with bronchial and bronchiolar epithelial attenuation, necrosis, hyperplasia, type II pneumocyte hyperplasia, numerous viral syncytia, and intranuclear and intracytoplasmic eosinophilic viral inclusions, mixed breed, caprine.

ETIOLOGIC DIAGNOSIS: Morbilliviral pneumonia

CAUSE: Peste des petits ruminants virus (PPRV)

SYNONYMS: Goat plague, ovine rinderpest, pseudorinderpest, stomatitis-pneumoenteritis complex, kata









For Pneumonias in small ruminants:



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