JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

October 2017

P-V04

 

Signalment (JPC #2295198): 9-month-old, mixed breed goa

HISTORY: This goat was found dead 8 days after being inoculated subcutaneously with 1.0 mL of blood product made from a goat with profound respiratory signs. The cranioventral lungs were consolidated and hyperemic. There was accumulation of fibrin on the overlying pleura.

HISTOPATHOLOGIC DESCRIPTION: Lung: Diffusely, alveolar septa are expanded up to three times normal by histiocytes and lymphocytes, there is necrosis and loss of type I pneumocytes and alveoli are lined by type II pneumocytes (hyperplasia). Multifocally replacing both alveolar pneumocytes and bronchiolar epithelium, there are numerous viral syncytia containing up to 30 nuclei. Multifocally, alveolar and bronchiolar epithelial syncytia, type II pneumocytes and bronchiolar epithelial cells contain intranuclear and intracytoplasmic, eosinophilic, oval viral inclusions up to 5 microns in diameter. Bronchial and bronchiolar epithelial cells have one or more of the following changes: attenuation, necrosis, and hyperplasia, which is often irregular and tortuous. Multifocally, the perivascular and peribronchiolar interstitium, interlobular septa, and pleura are expanded by edema, ectatic lymphatics, few neutrophils, lymphocytes, and rare plasma cells. Alveolar spaces, and occasionally bronchiolar lumina, are filled with an exudate composed of viable and degenerate neutrophils, necrotic cellular debris, and fibrin with fewer macrophages, occasional lymphocytes, hemorrhage, and edema.

MORPHOLOGIC DIAGNOSIS: Lung: Pneumonia, bronchointerstitial, lymphohistiocytic, diffuse, severe, with bronchial and bronchiolar epithelial attenuation, necrosis, hyperplasia, type II pneumocyte hyperplasia, numerous viral syncytia, and intranuclear and intracytoplasmic eosinophilic viral inclusions, mixed breed, caprine.

ETIOLOGIC DIAGNOSIS: Morbilliviral pneumonia

CAUSE: Peste des petits ruminants virus (PPRV)

SYNONYMS: Goat plague, ovine rinderpest, pseudorinderpest, stomatitis-pneumoenteritis complex, kata

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

For Pneumonias in small ruminants:

COMPARATIVE PATHOLOGY:

REFERENCES:

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  2. Bailey C, Mansfield K. Emerging and reemerging infectious diseases of nonhuman primates in the laboratory setting. Vet Pathol. 2010;47(3):462-481.
  3. Bossart BG. Marine mammals as sentinel species for oceans and human health. Vet Pathol. 2011; 48(3):676-690.
  4. Caswell JL, Williams KJ. The respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer"s Pathology of Domestic Animals. Vol. 2. 6th ed. Philadelphia, PA: Elsevier Saunders;2016:557.
  5. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO:Mosby; 2017:397.
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  8. Origgi FP, Plattet P, Sattler U, Robert N, Casaubon J, et al. Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores. Vet Pathol. 2012;49(6):913-929.
  9. Pesavento PA, Murphy BG. Common and emerging infectious diseases in the animal shelter. Vet Pathol. 2014; 51(2): 478.
  10. Rossiter PB, Taylor WP. Peste des petits ruminants. In: Coetzer JA, Thomson GR, Tustin RC, eds. Infectious Diseases of Livestock. 2nd ed. Cape Town, South Africa: Oxford University Press; 2004: 660-669.
  11. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier Limited; 2016:115,130-131.

 

 


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