JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-T09

Signalment (JPC# 2548860):  5-year-old male American Eider duck (Someteria mollisima dresseri)

HISTORY:  This duck was depressed.  A radiograph revealed a penny in the ventriculus.  The duck was treated with itraconazole, fluids, enrofloxacin, and calcium versonate.  There was no improvement over the next 10 days.  The penny was surgically removed, but the duck died 24 hours later.

HISTOPATHOLOGIC DESCRIPTION:  Pancreas and small intestine:  Diffusely affecting 70% of the pancreatic tissue is marked acinar cell atrophy and loss.  Atrophied acinar cells are characterized by shrunken, angular cytoplasm, decreased intensity of zymogen granule staining and loss of zymogen granules.  Surrounding, widely separating, compressing and distorting remaining islands of acini are broad bands of loose fibrous connective tissue and a marked increase in ductal epithelium.  Ductal cells are individualized or formed into variably-sized ducts (tubular complexes) and have round to oval, often crowded, vesiculate nuclei.  The small intestinal serosa and peripancreatic and peri-intestinal adipose tissue is mildly to moderately expanded by heterophils, lymphocytes, and macrophages admixed with hemorrhage, fibrin and scattered 1x 3 um bacilli.  Multifocally, there is atrophy of peripancreatic adipose tissue.   

MORPHOLOGIC DIAGNOSIS: 

  1. Pancreas, exocrine:  Acinar atrophy and loss, diffuse, marked, with extensive fibrosis and ductal cell proliferation, American Eider duck (Someteria mollisima dresseri), avian.
  2. Small intestine and adipose tissue: Serositis, fibrinous and heterophilic, diffuse, subacute, moderate, with bacilli.

ETIOLOGIC DIAGNOSIS:  Pancreatic zinc toxicosis

CAUSE:  Zinc intoxication

CONDITION SYNONYM:  New wire disease

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Bildfell RJ, et al. A review of episodes of zinc phosphide toxicosis in wild geese (Branta ) in Oregon (2004–2011). J Vet Diagn Invest. 2013; 25(1): 162–167.
  2. Blundell R, Adam F. Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog. Vet Rec. 2013; 172(1): 17.
  3. Garland T. Zinc. In: Gupta RC, ed. Veterinary Toxicology: Basic and Clinical Principles. New York, NY: Academic Press; 2007: 470-472.
  4. Gurnee CM, Drobatz KJ. Zinc intoxication in dogs: 19 cases (1991-2003). J Am Vet Med Assoc. 2007; 230:1174-1179.
  5. Jubb KV, Stent AW. Pancreas. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier Ltd; 2016:354-357.
  6. Sebastian MM. Role of pathology in diagnosis. In: Gupta RC, ed. Veterinary Toxicology: Basic and Clinical Principles. New York, NY: Academic Press; 2007:1112.


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