JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
February 2018
U-V04

Signalment (JPC #2051827):  2-month-old mangabey monkey

HISTORY:  This monkey died two weeks after sustaining a skull fracture.

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Segmentally affecting approximately 20% of the glomerular tufts, the mesangium is moderately thickened and expanded by hypereosinophilic fibrillary matrix that obscures capillary lumina (segmental glomerulosclerosis).  Within sclerotic glomeruli, there are few large cells with indistinct cell borders and a nucleus two to three times larger than adjacent cells.  These nuclei have marginated chromatin and a central, round to oval, up to 12 um in diameter, amphophilic to basophilic intranuclear inclusion body surrounded by a clear halo (Cowdry-type A or "owl's eye" inclusion).  Rare scattered tubules contain sloughed, shrunken, hypereosinophilic epithelial cells with pyknotic nuclei (necrosis).  There are rare previously described intranuclear inclusions present within tubular epithelial cells. There is a focus of lymphocytes with fewer plasma cells in the pericalyceal connective tissue. There are scattered subcapsular immature glomeruli (consistent with immaturity).

MORPHOLOGIC DIAGNOSIS:  Kidney:  Glomerulosclerosis, subacute, segmental, multifocal, mild with cytomegaly, karyomegaly, and intranuclear viral inclusion bodies, mangabey monkey, non-human primate.

ETIOLOGIC DIAGNOSIS:  Betaherpesviral nephritis

CAUSE:  Cytomegalovirus (CMV)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

For intranuclear inclusions with a degree of cytomegaly:

COMPARATIVE PATHOLOGY:

Cytomegaloviruses are species specific

References:

  1. Assaf BT, Knight HL, Miller AD. Rhesus cytomegalovirus (Macacine herpesvirus-3) associated facial neuritis in a simian immunodeficiency virus infected rhesus macaques. Vet Pathol. 2015; 52(1):217-223.
  2. Barry P, Marthas M, Lerche N, et al. Virology Research. In: Wolfe-Coote S ed. The Laboratory Primate, 4th ed. San Diego, CA: Elsevier Limited; 2005:569-572.
  3. Baskin GB: Cytomegalovirus infection in nonhuman primates. In: Jones TC, Mohr U, Hunt RD, eds. Monographs on Pathology of Laboratory Animals, Nonhuman Primates I. New York, NY: Springer-Verlag; 1993:32-37.
  4. Koyoma K, Horiuchi N, et al. Cytomegalic inclusion disease caused by cytomegalovirus infection in the salivary glands of an African hedgehog (Atelerix arbiventris). J Comp Pathol. 2017; 157:299-302.
  5. Kuhn EM, Stolte N, Matz-Rensing K, et al. Immunohistochemical studies of productive Rhesus Cytomegalovirus infection in rhesus monkeys (Macaca mulatta) infected with Simian Immunodeficiency Virus. Vet Pathol. 1999;36(1):51-6.
  6. Lerche NW. Common viral infections. In: Wolfe-Coote S ed. The Laboratory Primate, 4th ed. San Diego, CA: Elsevier Limited; 2005:81.
  7. Lopez A. Respiratory system, mediastinum, and pleura. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby; 2017:491-492.
  8. Murphy FA, Gibbs EPJ, Horzinek MC, Studdert MJ. Veterinary Virology. 3rd ed. San Diego, CA: Academic Press; 1999:31-32, 302, 322-324.
  9. Percy DH, Barthold SW. Pathology of Laboratory Rodents and Rabbits. 4rd ed. Ames, IA: Blackwell Publishers; 2016:15, 122, 175, 219.
  10. Wachtman L, Mansfield K. Viral diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardiff S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. San Diego, CA: Academic Press; 2012:19-20.

 

 


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