JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-T11

Signalment (# V51791):  Cow, age not specified

HISTORY:  While on pasture, this cow suddenly became febrile, developed hemorrhage from several body openings and subsequently died.

HISTOPATHOLOGIC DESCRIPTION:  Urinary bladder:  Focally extensively expanding the lamina propria and elevating the overlying urothelium is a proliferation of fibroblasts surrounded by mature collagen fibers and numerous small caliber blood vessels.  Focally there is a vague, nodular area of hemorrhage admixed with moderate numbers of lymphocytes, fewer macrophages and rare plasma cells, which also expand the submucosal connective tissue.  There is congestion and increased clear space with dilated lymphatics (edema), and frequently urothelial cells contain a large, intracytoplasmic clear vacuole (hydropic degeneration).  Multifocally, the tunica adventitia is expanded by few perivascular lymphocytes, plasma cells and macrophages.

MORPHOLOGIC DIAGNOSIS:  Urinary bladder:  Cystitis, hemorrhagic and lymphoplasmacytic, focally extensive, moderate, with fibrosis, breed not specified, bovine.

ETIOLOGIC DIAGNOSIS:  Toxic cystitis

CAUSE:  Chronic bracken fern toxicity

CONDITION:  Enzootic hematuria

GENERAL DISCUSSION: 

PATHOGENESIS:

Acute toxicity

Chronic toxicity

Esophageal squamous cell carcinoma associated with BoPV-4 and bracken fern

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS

DIFFERENTIAL DIAGNOSIS:

Causes of hematuria/hemoglobinuria in cattle:

COMPARATIVE PATHOLOGY:

References:

  1. Cantile C, Youssef S. Nervous system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Saunders Elsevier;2016:312-314.
  2. Cota JB, Carvalho T, Pinto C, and Peleteiro MC. Epithelial urinary bladder tumors from cows with enzootic hematuria: structural and cell cycle–related protein expression.  Vet Pathol.  2014;51(4):749-754.
  3. Faccin TC, Masuda EK, Piazer JVM, et al. Annular stenotic oesophageal squamous cell carcinoma in cattle exposed naturally to bracken fern (Pteridium arachnoideum). J Comp Pathol.  2017 Aug-Oct;157(2-3):174-180.
  4. Kelly PA, Toolan D, Jahns H. Intestinal adenocarcinoma in a herd of farmed Sika deer (Cervus nippon): a novel syndrome.  Vet Pathol.  2015;51(2):193-200.
  5. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Saunders Elsevier;2016:461-462.
  6. Munday JS. Bovine and human papillomaviruses: a comparative review.  Vet Pathol.  2014;51(6):1063-1075.
  7. Roperto S, Borzacchiello G, Brun R, et al. A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder. J Comp Path. 2010;142(2-3):95-108.
  8. Sasani F, Baghban F, Nikbakht Brujeni GH, Kazemi M. TP53 intronic mutations in bovine enzootic hematuria–associated urinary bladder tumors.  Vet Patho 2012;50(3):543-547.
  9. Scala C, Ortiz K, Catinaud J, Lemberger K. Hematuria and urinary bladder lesions compatible with bracken fern (Pteridium aquilinum) intoxication in captive fallow deer (Dama dama).  J Zoo Wildl Med.  2014 Jun;45(2):380-385.
  10. Wilcock BP, Njaa BL. Special senses. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Saunders Elsevier;2016:471.
  11. Wilson CJ, Flake GP, Sills RC, et al. Immunohistochemical expression of cyclin D1, cytokeratin 20 and uroplakin III in proliferative bladder lesions induced by o-Nitroanisole in Fischer 344/N rats.  Vet Pathol.  2016 May;53(3):682-690.

 

 


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