JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-M10 (NP)

SIGNALMENT (JPC #1901151): Beagle dog

HISTORY: Tissue from a 2-year-old female beagle dog used as a control in an inhalation toxicity study, and the histopathological changes were an incidental finding

HISTOPATHOLOGIC DESCRIPTION: Kidney: Multifocally, approximately 20% of glomeruli are variably and segmentally distorted and glomerular capillary lumina are compressed, expanded or obliterated by large, densely-packed foam cells within the mesangium which are up to 40 um in diameter with cytoplasm containing fine, clear microvacuoles with variably sized eosinophilic globules and granules. Foam cell nuclei are often pyknotic, and peripherally compressed. Occasionally, foam cells contain fine golden-yellow granules (lipofuscin). In the cortex, tubules are rarely mildly dilated, lined by attenuated epithelium, and filled with a homogenous, eosinophilic, hyalinized material (proteinosis). Tubules within the medulla rarely contain small deeply basophilic granular material (mineral).

MORPHOLOGIC DIAGNOSIS: Kidney, glomeruli: Vacuolar change, lipid-type, segmental, multifocal, moderate, with mesangial foam cells, beagle, canine

ETIOLOGIC DIAGNOSIS: Glomerular lipidosis

GENERAL:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURE: 

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

Hamsters:

Mice:

Cats:

References:

  1. 1. Brown TP; Fitzpatrick RK. Glomerular lipid emboli in a diabetic dog. Vet Pathol 1986;23:209-211.
  2. Cianciolo RE, Mohr CF. Urinary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. 6th ed. Vol 2, Philadelphia, PA: Elsevier; 2016:418-421.
  3. Furrow E, Lees GE, et al. Glomerular lesions in proteinuric miniature schnauzer dogs. Vet Pathol. 2017; 2017; 54(3):484-489.
  4. Kohnken RA, Armerman H, et al. Glomerular lipidosis in dogs. Vet Pathol. 2017; 45(4):795-801.
  5. Martino-Costa AL, Malhao F, et al. Renal interstitial lipid accumulation in cats with chronic kidney disease. J Comp Pathol. 2017; 157:75-79.
  6. McLeland SM, Cianciolo RE, et al. A comparison of biochemical and histopathologic staging in cats with chronic kidney disease. Vet Pathol. 2017; 52(3):524-534.
  7. Breshears MA, Confer AW. The urinary system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:653.
  8. Norimatsu M, Doi K, Itagaki K, Mitsuoka T. Glomerular lipidosis in a Syrian hamster of the APA strain. Lab Anim. 1990; 24:48-52.
  9. Rosol TJ, Grone A. Endocrine glands. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. 5th ed. Vol 3, Philadelphia, PA: Elsevier; 2016:319.
  10. Suárez-Bonnet A, Espinosa de los Monteros A, Herráez P, Rodríguez F, Andrada M, Caballero MJ. Fat embolism secondary to yellow fat disease in an Appaloosa horse. J Vet Diagn Invest. 2008 Sep; 20(5):684-7.

 

 


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