JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
MARCH 2018
H-B09 (NP)

Signalment (AFIP Accession #2145819):  Human, 27 year-old, sex unspecified

HISTORY: This veterinarian had a history of recent lymphadenopathy of the right axillary lymph node.

HISTOPATHOLOGIC DESCRIPTION:

H-B09a:  Lymph node, right axillary: 

Effacing approximately 50% of the nodal architecture, primarily within the cortex and paracortical areas, are multifocal to coalescing pyogranulomas, characterized by a central core of eosinophilic cellular and karyorrhectic debris (lytic necrosis), surrounded by and admixed with moderate numbers of viable and degenerate neutrophils with fewer macrophages, including epithelioid macrophages and rare multinucleated giant cells, few fibroblasts and fibrin. The remainder of the cortex is moderately hyperplastic with a few secondary follicles and expansion of the paracortical areas.  Medullary sinuses contain many histiocytes and there are multifocal areas of hemorrhage within the capsule, cortex, and medulla.

H-B09b: 

Warthin-Starry:  Multifocally, primarily within areas of necrosis, there are rare extracellular, silver-positive, 2 x 3 um bacilli.

MORPHOLOGIC DIAGNOSIS:  Lymph node, right axillary: Lymphadenitis, pyogranulomatous and necrotizing, multifocal to coalescing, moderate, with rare agyrophylic pleomorphic bacilli, human.

ETIOLOGIC DIAGNOSIS:  Bartonella lymphadenitis

CAUSE:  Bartonella henselae

CONDITION: Cat scratch disease (CSD)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:  

ADDITIONAL DIAGNOSTIC TESTS:

COMPARATIVE PATHOLOGY:

References:

  1. Breitschwerdt EB, Linder KL, Day MJ et al. Koch’s postulates and the pathogenesis of comparative infectious disease causation associated with Bartonella species. J Comp Pathol. 2013;148(2-3):115-125.
  2. Buchmann AU, Kempf VAJ, Kershaw O, Gruber AD. Peliosis hepatis in cats is not associated with Bartonella henselae infections. Vet Pathol. 2010;47:163-166.
  3. Craig LE, Dittmer KE, Thompson KG. Bones and joints. In: Maxie MG, Ed.  Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St Louis, MO: Elsevier; 2016: 99.
  4. Cullen JM, Stalker MJ. Livery and biliary system. In: Maxie MG, Ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St Louis, MO: Elsevier; 2016: 318
  5. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, Ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St Louis, MO: Elsevier; 2016: 646. 
  6. Pultorak EL, Linder K, Maggi RG et al., Prevalence of Bartonella spp in canine cutaneous histiocytoma. J Comp Pathol. 2015:153: 14-21.
  7. Robinson WF, Robinson NA. Cardiovascular system. In: Maxie MG, Ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St Louis, MO: Elsevier; 2016: 31,42
  8. Varanat M, Broadhurst J, Linder KE, et al. Identification of Bartonella henselae in 2 cats with pyogranulomatous myocarditis and diaphragmatic myositis. Vet Pathol. 2012; 49(4):608-611.

 


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