JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
August 2018
D-B04

 

Signalment (AFIP #2010741):  6-week-old calf

HISTORY:  Animal was observed with abdominal distension and sunken eyes shortly before death.

HISTOPATHOLOGIC DESCRIPTION:  Abomasum (fundus):  Diffusely and transmurally, but most prominently within the submucosa, the abomasum is markedly expanded by increased clear space and ectatic lymphatics (edema) and vessels, and eosinophilic finely fibrillar material (fibrin); moderate to high numbers of degenerate and viable neutrophils infiltrate the mucosa and submucosa and extend into the tunica muscularis and serosa.  Multifocally within the mucosa there is a loss of differential staining with retention of architecture and/or replacement of mucosal epithelium by karryorhectic and cellular debris (necrosis), neutrophils, and hemorrhage.  In the deep mucosa, at the level of the gastric glands, are variably sized up to 300um round to oval well defined areas of clear space (emphysema).  Diffusely throughout the abomasum within small and intermediate sized vessels, the endothelium is discontinuous, fragmented and necrotic and there is infiltration of the tunica media by numerous degenerate and fewer viable neutrophils, fibrin and karryorhectic and cellular debris, which multifocally extend into the tunica externa (vasculitis).

MORPHOLOGIC DIAGNOSIS:  Abomasum (fundus):  Abomasitis, necrohemorrhagic, acute, transmural, diffuse, moderate, with emphysema, marked submucosal edema and vasculitis, breed unspecified, bovine.

ETIOLOGIC DIAGNOSIS:  Clostridial abomasitis

CAUSE:  Clostridium septicum

CONDITION:  Braxy, bradsot

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSIS TESTS:

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Garcia JP, Moore J, Loukopoulos P, Diab SS, Uzal FA. Necrotizing gastritis associated with Clostridium septicum in a rabbit. J Vet Diagn Invest. 2014;26(5):669-673.
  2. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF, McGavin MD, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier Mosby; 2017:362.
  3. Gornatti-Churria CD, Crispo M, Shivaprasad HL, Uzal A. Gangrenous dermatitis in chickens and turkeys. J Vet Diagn Invest. 2018;30(2):188-196.
  4. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:53.

 


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