JPC SYSTEMIC PATHOLOGY
MUSCULOSKELETAL SYSTEM
April 2019
M-T06

SIGNALMENT (JPC #1948317):  4-week-old broiler chicken

HISTORY:  This chicken had been fed a ration containing Fusarium roseum since one day of age. There was marked accumulation of avascular physeal cartilage in the growth plates of long bones, especially the proximal tibiotarsus, and the diaphyses were well mineralized.

HISTOPATHOLOGIC DESCRIPTION:  Tibia: The proximal physis is markedly expanded up to 1cm by a dense mass of avascular physeal cartilage characterized by a thickened zone of proliferation that fails to form fully mature hypertrophied chondrocytes, and does not undergo mineralization. The mass of cartilage protrudes deep into the proximal metaphysis and primary spongiosa are thickened and irregular and have many retained chondrocytes within the cartilage matrix. Metaphyseal capillary loops are markedly widened and end abruptly at the cartilaginous junction. Within the metaphysis and diaphysis, there are reduced numbers of osteoclasts, and bony trabeculae are thickened (osteosclerosis) and lined by dense bands of osteoblasts. Multifocally there is a moderate amount of retained, unmineralized cartilage matrix, much of which has retained chondrocytes, within bony diaphyseal trabeculae.

MORPHOLOGIC DIAGNOSIS:  Tibia, physis: Failure of endochondral ossification, focally extensive, marked, with proliferation of prehypertrophic chondrocytes, decreased mineralization, and blunted physeal vessels, chicken, avian.

ETIOLOGIC DIAGNOSIS:  Toxic tibial chondrodysplasia

CAUSE:  Fusarochromanone toxin elaborated by Fusarium sp.

CONDITION:  Tibial dyschondroplasia

SYNONYM:  Tibial chondrodysplasia

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS: 

For thickened growth plates or bone:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Huang S, et al. Role of angiopoietin-like 4 on bone vascularization in chickens exposed to high-altitude hypoxia. J Comp Path. 2018;161:25-33.
  2. Shivaprasad HL, Crespo R. Developmental, metabolic, and other noninfectious disoders In: Swayne DE, Glisson JR, McDougald LR, Nolan LK Suarez DL, Nair V, eds. Diseases of Poultry. 13th ed. Ames, IA: John Wiley & Sons, Inc.; 2013:1238-1240.
  3. Shivaprasad HL. Miscellaneous diseases. In: Boulianne M, ed. Avian Disease Manual. 7th ed. Athens, GA: American Association of Avian Pathologists; 2013:211, 216.


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