JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES
April 2018
S-M17

Signalment (JPC #2840045):  2.6-week-old Fvb/NCr mouse

HISTORY:  Tissue from a mouse that was normal clinically and grossly. 

HISTOPATHOLOGIC DESCRIPTION:  Eyes:  Diffusely the retina is 1/2 the normal thickness with loss of the outer plexiform, outer nuclear, and photoreceptor layers. 

HISTOPATHOLOGIC DIAGNOSIS:  Eye, retina: Degeneration and atrophy, diffuse, severe, characterized by loss of the outer plexiform, outer nuclear, and photoreceptor layers, Fvb/NCr mouse, rodent.

ETIOLOGIC DIAGNOSIS:  Hereditary outer retinal atrophy.

CAUSE:  Autosomal recessive gene (homozygous rd-1 allele)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. DiSalvo AR, Reilly CM, Wiggans KT, Woods LW, Wack RF, Clifford DL. Photoreceptor degeneration in a mountain lion cub (Puma concolor). Journal of Zoo and Wildlife Medicine. 2016;47(4):1077-1080.
  2. Dubielzig RR, Ketring KL, McLellan GJ, Albert DM. Veterinary Ocular Pathology: A Comparative Review. Louis, MO: Saunders Elsevier; 2010:354-369.
  3. Fielden M, et al. Retinal toxicity induced by a novel b-secretase inhibitor in the Sprague-Dawley rat.  Tox Path. 2014; XX: 1-12.
  4. Labelle P. The eye. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO:  Mosby Elsevier; 2016:1315-1316.
  5. Mudry MC, Kronenburg S, Komatsu S, Aguierre GD. Blinded by the light: retinal phototoxicity in the context of safety studies. Tox Path.  2013; 41: 813-825.
  6. Narfstrom K, Petersen-Jones M. Diseases of the canine ocular fundus. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th Ames, IA: John Wiley & Sons, Inc.; 2013:1323-1351.
  7. Rajan I, Read R, Small DL, Perrard J, Vogel P. An alternative splicing variant in Clcn7–/– mice prevents osteopetrosis but not neural and retinal degenerate on. Vet Pathol. 2011;48(3)663-675.
  8. Vogel P, et al. Nephronophthisis and retinal degeneration in Tmem218–/– mice: a novel mouse model for Senior-Løken syndrome?.  Vet Pathol On-line.  2014; 1-16.
  9. Wunschmann A, Armien AG, Khatri M, et al. Ocular lesions in red-tailed hawks (Buteo jamaicensis) with naturally acquired west nile disease. Veterinary Pathology. 2017;54(2):277-287.
  10. Yang L, et al. Nicotine alters morphology and function of retinal pigment epithelial cells in mice. Tox Path.  2010;38:560-567.
  11. Yoshizawa K, et al. Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-Ethyl-N-Nitrosourea.  Tox Path. 2011;39:606-613.
  12. Ziess ZJ. Review paper: animals as models of age-related macular degeneration: an imperfect measure of the truth. Vet Patho  2010;47(3)396-413.


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